Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves

Published on Oct 1, 2021in Computer Methods in Applied Mechanics and Engineering6.756
路 DOI :10.1016/J.CMA.2021.113960
Emily L. Johnson6
Estimated H-index: 6
(Iowa State University),
Devin W. Laurence8
Estimated H-index: 8
(OU: University of Oklahoma)
+ 5 AuthorsMing-Chen Hsu40
Estimated H-index: 40
(Iowa State University)
Sources
Abstract
Abstract null null Approximately 1.6 million patients in the United States are affected by tricuspid valve regurgitation, which occurs when the tricuspid valve does not close properly to prevent backward blood flow into the right atrium. Despite its critical role in proper cardiac function, the tricuspid valve has received limited research attention compared to the mitral and aortic valves on the left side of the heart. As a result, proper valvular function and the pathologies that may cause dysfunction remain poorly understood. To promote further investigations of the biomechanical behavior and response of the tricuspid valve, this work establishes a parameter-based approach that provides a template for tricuspid valve modeling and simulation. The proposed tricuspid valve parameterization presents a comprehensive description of the leaflets and the complex chordae tendineae for capturing the typical three-leaflet structural deformation observed from medical data. This simulation framework develops a practical procedure for modeling tricuspid valves and offers a robust, flexible approach to analyze the performance and effectiveness of various valve configurations using isogeometric analysis. The proposed methods also establish a baseline to examine the tricuspid valve鈥檚 structural deformation, perform future investigations of native valve configurations under healthy and disease conditions, and optimize prosthetic valve designs.
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References89
Newest
#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Brennan T. Mullins (OU: University of Oklahoma)H-Index: 1
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
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Abstract Collagen fibers are the primary load-bearing microstructural constituent of bodily soft tissues, and, when subjected to external loading, the collagen fibers reorient, uncrimp, and elongate. Specific to the atrioventricular heart valve leaflets, the collagen fiber kinematics form the basis of many constitutive models; however, some researchers claim that modeling the affine fiber kinematics (AFK) are sufficient for accurately predicting the macroscopic tissue deformations, while others ...
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#1Wenbo Zhang (University of Texas at Austin)H-Index: 5
#2Giovanni Rossini (Polytechnic University of Milan)H-Index: 1
Last. Michael S. Sacks (University of Texas at Austin)H-Index: 90
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The functional complexity of native and replacement aortic heart valves are well known, incorporating such physical phenomenons as time-varying non-linear anisotropic soft tissue mechanical behavior, geometric non-linearity, complex multi-surface time varying contact, and fluid-structure interactions to name a few. It is thus clear that computational simulations are critical in understanding AV function and for the rational basis for design of their replacements. However, such approaches continu...
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#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Ming-Chen Hsu (Iowa State University)H-Index: 40
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
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Atrioventricular heart valves (AHVs) regulate the unidirectional flow of blood through the heart by opening and closing of the leaflets, which are supported in their functions by the chordae tendineae (CT). The leaflets and CT are primarily composed of collagen fibers that act as the load-bearing component of the tissue microstructures. At the CT-leaflet insertion, the collagen fiber architecture is complex, and has been of increasing focus in the previous literature. However, these previous stu...
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#1David Kamensky (UCSD: University of California, San Diego)H-Index: 18
Abstract We recently developed the open-source library tIGAr, which extends the FEniCS finite element automation framework to isogeometric analysis. The present contribution demonstrates the utility of tIGAr in complex problems by applying it to immersogeometric fluid鈥搒tructure interaction (FSI) analysis. This application is implemented as the new open-source library CouDALFISh (Coupling, via Dynamic Augmented Lagrangian, of Fluids with Immersed Shells, pronounced 鈥渃uttlefish鈥), which uses the d...
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#1Emily L. Johnson (Iowa State University)H-Index: 6
#2Michael C.H. Wu (Iowa State University)H-Index: 11
Last. Ming-Chen Hsu (Iowa State University)H-Index: 40
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Valvular heart disease has recently become an increasing public health concern due to the high prevalence of valve degeneration in aging populations. For patients with severely impacted aortic valves that require replacement, catheter-based bioprosthetic valve deployment offers a minimally invasive treatment option that eliminates many of the risks associated with surgical valve replacement. Although recent percutaneous device advancements have incorporated thinner, more flexible biological tiss...
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#1Luke T. Hudson (OU: University of Oklahoma)H-Index: 2
#2Samuel Jett (OU: University of Oklahoma)H-Index: 5
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
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The tricuspid valve (TV) is composed of three leaflets that coapt during systole to prevent deoxygenated blood from re-entering the right atrium. The connection between the TV leaflets鈥 microstructure and the tissue-level mechanical responses has yet to be fully understood in the TV biomechanics society. This pilot study sought to examine the load-dependent collagen fiber architecture of the three TV leaflets, by employing a multiscale, combined experimental approach that utilizes tissue-level b...
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#1Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
#2Emily L. Johnson (Iowa State University)H-Index: 6
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
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Current clinical assessment of functional tricuspid valve regurgitation relies on metrics quantified from medical imaging modalities. Although these clinical methodologies are generally successful, the lack of detailed information about the mechanical environment of the valve presents inherent challenges for assessing tricuspid valve regurgitation. In the present study, we have developed a finite element-based in silico model of one porcine tricuspid valve (TV) geometry to investigate how variou...
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#1Takuya Terahara (Waseda University)H-Index: 8
#2Kenji Takizawa (Waseda University)H-Index: 61
Last. Kensuke Shiozaki (Waseda University)H-Index: 2
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We address the computational challenges of and presents results from ventricle-valve-aorta flow analysis. Including the left ventricle (LV) in the model makes the flow into the valve, and consequently the flow into the aorta, anatomically more realistic. The challenges include accurate representation of the boundary layers near moving solid surfaces even when the valve leaflets come into contact, computation with high geometric complexity, anatomically realistic representation of the LV motion, ...
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#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Junnan Zheng (ZJU: Zhejiang University)H-Index: 1
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
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The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have is...
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#1Yuxuan Yu (CMU: Carnegie Mellon University)H-Index: 1
#2Yongjie Jessica Zhang (CMU: Carnegie Mellon University)H-Index: 1
Last. Takafumi Sasaki (Waseda University)H-Index: 10
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Patient-specific computational flow analysis of coronary arteries with time-dependent medical-image data can provide valuable information to doctors making treatment decisions. Reliable computational analysis requires a good core method, high-fidelity space and time discretizations, and an anatomically realistic representation of the lumen motion. The space鈥搕ime variational multiscale (ST-VMS) method has a good track record as a core method. The ST framework, in a general context, provides highe...
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#1Emily L. JohnsonH-Index: 6
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#1Ning Liu (Princeton University)H-Index: 3
#2Emily L. Johnson (Iowa State University)H-Index: 6
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Abstract null null The computational modeling of thin-walled structures based on isogeometric analysis (IGA), non-uniform rational B-splines (NURBS), and Kirchhoff鈥揕ove (KL) shell formulations has attracted significant research attention in recent years. While these methods offer numerous benefits over the traditional finite element approach, including exact representation of the geometry, naturally satisfied high-order continuity within each NURBS patch, and computationally efficient rotation-f...
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