Devin W. Laurence
University of Oklahoma
AnatomyInternal medicineBiomedical engineeringGlycosaminoglycanBlood flowCardiologyBiomechanicsChemistryExtracellular matrixMaterials scienceAneurysmHeart valveArteryPapillary muscleMitral valveSubarachnoid hemorrhageOptical coherence tomographyvalvular heart diseaseElastinTricuspid valveHeart diseaseRegurgitation (circulation)Chordae tendineaePosterior inferior cerebellar arteryRight posteriorTricuspid Valve RegurgitationAtrioventricular valveTissue mechanicsComputer scienceMedicine
21Publications
8H-index
149Citations
Publications 23
Newest
#1Luke T. Hudson (OU: University of Oklahoma)H-Index: 2
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
view all 6 authors...
Abstract null null The semilunar heart valves regulate the blood flow from the ventricles to the major arteries through the opening and closing of the scallop shaped cusps. These cusps are composed of collagen fibers that act as the primary loading-bearing component. The load-dependent collagen fiber architecture has been previously examined in the existing literature; however, these studies relied on chemical clearing and tissue modifications to observe the underlying changes in response to mec...
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#1Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
#2Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
The tricuspid valve (TV) regulates the blood flow within the right side of the heart. Despite recent improvements in understanding TV mechanical and microstructural properties, limited attention has been devoted to the development of TV-specific constitutive models. The objective of this work is to use the first-of-its-kind experimental data from constant invariant-based mechanical characterizations to determine a suitable invariant-based strain energy density function (SEDF). Six specimens for ...
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#1Emily L. Johnson (Iowa State University)H-Index: 6
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Ming-Chen Hsu (Iowa State University)H-Index: 40
view all 8 authors...
Abstract null null Approximately 1.6 million patients in the United States are affected by tricuspid valve regurgitation, which occurs when the tricuspid valve does not close properly to prevent backward blood flow into the right atrium. Despite its critical role in proper cardiac function, the tricuspid valve has received limited research attention compared to the mitral and aortic valves on the left side of the heart. As a result, proper valvular function and the pathologies that may cause dys...
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#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Keely A. Laurence (OU: University of Oklahoma)
view all 18 authors...
Abstract null null The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of blood through a coordination of the extracellular matrix components, including the collagen fibers, elastin, and glycosaminoglycans. Dysfunction of the AHVs, such as those caused by unfavorable microstructural remodeling, lead to valvular heart diseases and improper blood flow, which can ultimately cause heart failure. In order to better understand the mechanics and remodeling of the ...
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#1Qizhi He (UCSD: University of California, San Diego)H-Index: 8
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Jiun-Shyan Chen (UCSD: University of California, San Diego)H-Index: 50
view all 4 authors...
Abstract Data-driven modeling directly utilizes experimental data with machine learning techniques to predict a material’s response without the necessity of using phenomenological constitutive models. Although data-driven modeling presents a promising new approach, it has yet to be extended to the modeling of large-deformation bio-tissues. Herein, we extend our recent local convexity data-driven (LCDD) framework (( He and Chen, 2020 ) to model the mechanical response of a porcine heart mitral va...
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#1Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
#2Hannah B. Homburg (University of Oklahoma Health Sciences Center)H-Index: 4
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
view all 8 authors...
Intracranial aneurysms (ICAs) are focal dilatations that imply a weakening of the brain artery. Incidental rupture of an ICA is increasingly responsible for significant mortality and morbidity in the American’s aging population. Previous studies have quantified the pressure-volume characteristics, uniaxial mechanical properties, and morphological features of human aneurysms. In this pilot study, for the first time, we comprehensively quantified the mechanical, collagen fiber microstructural, and...
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#1Grace A. Duginski (OU: University of Oklahoma)H-Index: 1
#2Colton J. Ross (OU: University of Oklahoma)H-Index: 7
Last. Rouzbeh Amini (NU: Northeastern University)H-Index: 16
view all 16 authors...
The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of blood through a subtle coordination of the tissue's extracellular matrix (ECM) components, including collagen fibers, elastin fibers, and glycosaminoglycans. Dysfunction of the AHVs, such as those caused by unfavorable microstructural remodeling, results in valvular heart diseases and improper blood flow that can eventually lead to heart failure. To better understand mechanics and remodeling of the AHV ...
Source
#1Luke T. Hudson (OU: University of Oklahoma)H-Index: 2
#2Samuel Jett (OU: University of Oklahoma)H-Index: 5
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
view all 12 authors...
The tricuspid valve (TV) is composed of three leaflets that coapt during systole to prevent deoxygenated blood from re-entering the right atrium. The connection between the TV leaflets’ microstructure and the tissue-level mechanical responses has yet to be fully understood in the TV biomechanics society. This pilot study sought to examine the load-dependent collagen fiber architecture of the three TV leaflets, by employing a multiscale, combined experimental approach that utilizes tissue-level b...
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#1Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
#2Emily L. Johnson (Iowa State University)H-Index: 6
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
view all 9 authors...
Current clinical assessment of functional tricuspid valve regurgitation relies on metrics quantified from medical imaging modalities. Although these clinical methodologies are generally successful, the lack of detailed information about the mechanical environment of the valve presents inherent challenges for assessing tricuspid valve regurgitation. In the present study, we have developed a finite element-based in silico model of one porcine tricuspid valve (TV) geometry to investigate how variou...
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#1Colton J. Ross (OU: University of Oklahoma)H-Index: 7
#2Devin W. Laurence (OU: University of Oklahoma)H-Index: 8
Last. Chung-Hao Lee (OU: University of Oklahoma)H-Index: 18
view all 10 authors...
Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as individual structures, usually in a clamping-based a...
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