Piwi-interacting RNA

RNA-Directed DNA Methylation

Arabidopsis

Biology

Gene

Germline

Mutant

Gene expression

Genome

DNA methylation

Germ cell

Epigenetics

Transposable element

Genetics

Science

Germline defense against transposons Genomes of germ cells present an existential vulnerability to organisms because germ cell mutations will propagate to future generations. Transposable elements are one source of such mutations. In the small flowering plant Arabidopsis , Long et al. found that genome methylation in the male germline is directed by small interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective by Mosher). These germline siRNAs silence germline transposons and establish inherited methylation patterns in sperm, thus maintaining the integrity of the plant genome across generations. Science , abh0556, this issue p. eabh0556 ; see also abj5020, p. 26

Nurse cell­–derived small RNAs define paternal epigenetic inheritance in <i>Arabidopsis</i>

Nurse cell­–derived small RNAs define paternal epigenetic inheritance in Arabidopsis

Nurse cell–derived small RNAs define paternal epigenetic inheritance in Arabidopsis