Ca²⁺‐activated K⁺ channel K_Ca1.1 as a therapeutic target to overcome chemoresistance in three‐dimensional sarcoma spheroid models

The large‐conductance Ca 2+ ‐activated K + channel K Ca 1.1 plays a pivotal role in tumor development and progression in several solid cancers. The three‐dimensional (3D) in vitro cell culture system is a powerful tool for cancer spheroid formation, and mimics in vivo solid tumor resistance to chemotherapy in the tumor microenvironment (TME). K Ca 1.1 is functionally expressed in osteosarcoma and chondrosarcoma cell lines. K Ca 1.1...