FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway
Abstract
N6-methyladenosine (m6A) modification plays a critical role in mammalian development. However, the role of m6A in the skeletal muscle development remains largely unknown. Here, we report a global m6A modification pattern of goat skeletal muscle at two key development stages and identified that the m6A modification regulated the expression of the growth arrest and DNA damage-inducible 45B (GADD45B) gene, which is involved in myogenic...
Paper Details
Title
FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway
Published Date
Dec 1, 2021
Volume
26
Pages
34 - 48
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