Clinical efficacy of intravitreal corticoid as an adjunctive therapy to anti-VEGF treatment of neovascular age-related macular degeneration: a Meta-analysis

Published on Jan 1, 2021in International Journal of Ophthalmology1.33
· DOI :10.18240/IJO.2021.07.19
Bo-Hao Cui , Wei Zhou (Tianjin Medical University General Hospital)+ 4 AuthorsHua Yan12
Estimated H-index: 12
(Tianjin Medical University General Hospital)
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Abstract
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Importance To our knowledge, this is the first randomized clinical trial to compare visual outcomes and injection loads between ranibizumab and aflibercept using an identical treat-and-extend (TE) regimen for neovascular age-related macular degeneration (nAMD). Objective To report the results of the preplanned 12-month interim analysis of 2 predefined secondary efficacy end points of a randomized clinical trial. Design, Setting, and Participants The Comparison of Ranibizumab and Aflibercept for ...
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Purpose Age-related macular degeneration (AMD) can cause irreversible vision loss leading to blindness. We aim to evaluate the efficacy and safety of intravitreal injections of 0.5 mg conbercept, a new anti–vascular endothelial growth factor (anti-VEGF) drug, for treatment of AMD on a schedule more manageable for patients. Design A prospective, double-masked, multicenter, sham-controlled, phase III randomized trial. Methods Patients : Patients with choroidal neovascularization (CNV) secondary to...
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Purpose. To evaluate the efficacy and safety of a single intravitreal dexamethasone implant (DXI) combined with intravitreal antivascular endothelial growth factor (anti-VEGF) therapy, in patients with neovascular age-related macular degeneration (wet-AMD) resistant to conventional treatment. Methods. In this randomized, controlled pilot study, 16 eyes of 15 patients, unresponsive to anti-VEGF therapy, were enrolled and randomly assigned to two groups: DXI
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Among the retinal vascular diseases, burden of retinal vein occlusion is most common immediately after diabetic retinopathy. Intravitreal corticosteroids are gaining popularity in managing macular edema (ME) of RVO. Our study compares efficacy and safety of intravitreal triamcinolone (IVTA) and dexamethasone implant (IVD) over 6 months. This comparative, prospective, randomized study on 40 patients of non-ischemic central RVO with significant ME (> 330 μm) of 35 mmHg and 66% needed combination t...
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