Brothers in arms: platelets and neutrophils in ischemic stroke

In this review, we will describe how the combined ability of platelets and neutrophils to interact with each other drives ischemic stroke brain injury.Neutrophils are one of the first cells to respond during ischemic stroke. Although animals stroke models have indicated targeting neutrophils improves outcomes, clinical trials have failed to yield successful strategies. Platelets play a critical role in recruiting neutrophils to sites of injury...