Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial

To determine whether dietary interventions that increase n-3 fatty acids with and without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in headache pathogenesis, and decrease headache in adults with migraine.Three arm, parallel group, randomized, modified double blind, controlled trial.Ambulatory, academic medical center in the United States over 16 weeks.182 participants (88% women, mean age 38 years) with...