1,2,3,4‐Tetrahydroisoquinoline Derivatives as a Novel Deoxyribonuclease I Inhibitors

Herein we report an assessment of 24 1,2,3,4‐tetrahydroisoquinoline derivatives for potential DNase I (deoxyribonuclease I) inhibitory properties in vitro . Four of them inhibited DNase I with IC 50 values below 200 μM. The most potent was 1‐(6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinolin‐1‐yl)propan‐2‐one ( 2 ) (IC 50 =134.35±11.38 μM) exhibiting slightly better IC 50 value compared to three other active compounds,...