Review paper
Drugging the Undruggable: Advances on RAS Targeting in Cancer
Abstract
Around 20% of all malignancies harbour activating mutations in RAS isoforms. Despite this, there is a deficiency of RAS-targeting agents licensed for therapeutic use. The picomolar affinity of RAS for GTP, and the lack of suitable pockets for high-affinity small-molecule binding, precluded effective therapies despite decades of research. Recently, characterisation of the biochemical properties of KRAS-G12C along with discovery of its ‘switch-II...
Paper Details
Title
Drugging the Undruggable: Advances on RAS Targeting in Cancer
Published Date
Jun 10, 2021
Journal
Volume
12
Issue
6
Pages
899 - 899
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Notes
History