Modeling NASH and NASH-Induced Hepatocellular Carcinoma: Faster and Better

Nonalcoholic steatohepatitis (NASH), a more severe manifestation of nonalcoholic fatty liver disease, is defined by excessive liver fat accumulation, lobular inflammation, and hepatocyte ballooning with or without perisinusoidal fibrosis. Progressive liver injury in NASH can eventually lead to cirrhosis, which confers an increased risk of developing hepatocellular carcinoma (HCC). Given the increasing prevalence of NASH, NASH-induced HCC is...