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Original paper

PI3K inhibitors are finally coming of age

Volume: 20, Issue: 10, Pages: 741 - 769
Published: Jun 14, 2021
Abstract
Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has been hampered by issues such as poor drug tolerance and drug resistance, several PI3K inhibitors have now received regulatory approval — the PI3Kα isoform-selective inhibitor alpelisib for the treatment of breast cancer and inhibitors mainly aimed at the leukocyte-enriched...
Paper Details
Title
PI3K inhibitors are finally coming of age
Published Date
Jun 14, 2021
Volume
20
Issue
10
Pages
741 - 769
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