Chemistry

Olefin metathesis

Salt metathesis reaction

Lewis acids and bases

Polymerization

Catalysis

Alkene

Cycloaddition

Metathesis

Organic chemistry

Olefin fiber

Combinatorial chemistry

Polymer

Chemical Reviews

This Review describes the development of strategies for carbonyl–olefin metathesis reactions relying on stepwise, stoichiometric, or catalytic approaches. A comprehensive overview of currently available methods is provided starting with Paternò–Büchi cycloadditions between carbonyls and alkenes, followed by fragmentation of the resulting oxetanes, metal alkylidene-mediated strategies, [3 + 2]-cycloaddition approaches with strained hydrazines as organocatalysts, Lewis acid-mediated and Lewis acid-catalyzed strategies relying on the formation of intermediate oxetanes, and protocols based on initial carbon–carbon bond formation between carbonyls and alkenes and subsequent Grob-fragmentations. The Review concludes with an overview of applications of these currently available methods for carbonyl–olefin metathesis in complex molecule synthesis. Over the past eight years, the field of carbonyl–olefin metathesis has grown significantly and expanded from stoichiometric reaction protocols to efficient catalytic strate...

Carbonyl–Olefin Metathesis