Ca 2+ ‐Activated Cl‐ Channel Anoctamin‐1 Interacts with Mitochondrial Fusion Protein OPA1

Anoctamin-1 (Ano1) forms a Ca2+-activated chloride channel found at the plasma membrane (PM) of several different cell types, including endothelial cells (ECs). We previously showed Ano1 overexpression in pulmonary artery ECs isolated from patients with idiopathic pulmonary arterial hypertension (PAH), which may be associated with hyperproliferative phenotype of pulmonary artery ECs in PAH. However, the detailed molecular mechanisms explaining...