Original paper
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
Abstract
R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause transcription-replication conflicts and give rise to genomic instability, particularly at telomeres, which are prone to forming DNA secondary structures. Here, we demonstrate that BRCA1 binds TERRA RNA, directly and physically via its N-terminal nuclear localization sequence, as well as...
Paper Details
Title
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
Published Date
Jun 10, 2021
Journal
Volume
12
Issue
1
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Notes
History