High Fecal Proteolytic Activity That Precedes Ulcerative Colitis Likely Results From Impaired Inactivation of Pancreatic Proteases Rather Than Bacteria

I read with great interest the cohort study by Galipeau et al1 entitled “Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis,” recently published in Gastroenterology, which found increased fecal proteolytic activity preceding the clinical diagnosis of ulcerative colitis along with changes in gut microbiota. I take a special interest in their article because I have suspected for a long time that increased proteases in...