Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Abstract
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial organoids. SARS-CoV-2 initially...
Paper Details
Title
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Published Date
Jun 15, 2021
Volume
218
Issue
8
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