Integrating multiple-chromatographic approaches to evaluate chemical consistency of Chang-Kang-Fang preparations from mixed-herb decoction and combined single-herb decoction

• Multi-chromatographic approaches were integrated to compare chemical profiles between MHD and cSHD. • Polysaccharides and small molecules were qualitatively identical between MHD and cSHD. • The contents of albiflorin, paeoniflorin and alkaloids in MHD were lower than those in cSHD. • The content of polysaccharides in MHD was higher than that in cSHD. Chang-Kang-Fang formula (CKF), a multi-herbs traditional Chinese medicine (TCM) prescription...