Journal of Pharmaceutical and Biomedical Analysis
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#1Gabriella Gerzon (York University)
#2Yi Sheng (York University)H-Index: 24
Last. Marina Kirkitadze (Sanofi Pasteur)H-Index: 5
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Abstract null null Process Analytical Technology (PAT) instruments include analyzers capable of measuring physical and chemical process parameters and key attributes with the goal of optimizing process controls. PAT in the form of a probe or sensor is designed to integrate within the pharmaceutical manufacturing line and is coupled with computing equipment to perform chemometric modeling for result interpretation and multilayer statistical control of processes. PAT solutions are intended for und...
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#1Hyun-Hee LimH-Index: 10
#2Kyeong-Yun Choi (KNU: Kongju National University)
Last. Ho-Sang Shin (KNU: Kongju National University)H-Index: 14
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Abstract null null A gas chromatography–mass spectrometric (GC–MS) method was developed for the qualitative and quantitative analysis of flavor chemicals in tobacco heating products (THPs), traditional tobacco products (TTPs) and their flavoring capsules. A total of 283 compounds were identified through non-target analysis, and the final 302 compounds were selected to develop an analytical method. The lower limits of detection (LOD) of analytes were 0.00074–12 mg/kg and their LOD range was wide ...
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#1Li Hou (GXNU: Guangxi Normal University)H-Index: 4
#2Xuanhan Zhang (GXNU: Guangxi Normal University)H-Index: 2
Last. Shulin Zhao (GXNU: Guangxi Normal University)H-Index: 58
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Abstract null null A sensitive and ratiometric electrochemical biosensor was developed for the determination of dimethoate via alkaline phosphatase (ALP) mediated dissolution of nano-MnO2 and [Ru(NH3)6]3+(Ru(III)) redox recycling. The electroactive probe Ru(III) was adsorbed on the nano-MnO2 with the high specific surface area through electrostatic interaction to form the MnO2-Ru(III) nanocomposite, which was then fixed on the surface of the glassy carbon electrode. When the dimethoate inhibited...
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#1Andrea Speltini (UNIPV: University of Pavia)H-Index: 24
#2Giuseppe Tripodo (UNIPV: University of Pavia)H-Index: 23
Last. Enrica Calleri (UNIPV: University of Pavia)H-Index: 25
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Abstract null null This paper deals with the preparation of new composites between polymerized/crosslinked high internal phase emulsions (polyHIPEs) and carbon nanotubes (CNTs), specifically designed for pharmaceutical analytical applications. While the composition of the polyHIPEs was maintained constant, the amount of CNTs was varied from 0.5% to 1% w/v. As proof-of-concept, the materials were tested for solid-phase extraction. Three drugs with different physical-chemical properties, namely 17...
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#1Joseph P. Smith (MSD: Merck & Co.)H-Index: 8
#2Nicole M. Ralbovsky (MSD: Merck & Co.)
Last. Narayan Variankaval (MSD: Merck & Co.)H-Index: 12
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Recent advances in biocatalysis and directed enzyme evolution has led to a variety of enzymatically-driven, elegant processes for active pharmaceutical ingredient (API) production. For biocatalytic processes, quantitation of any residual protein within a given API is of great importance to ensure process robustness and quality, pure pharmaceutical products. Typical analytical methods for analyzing residual enzymes within an API, such as enzyme-linked immunosorbent assays (ELISA), colorimetric as...
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#1Milan Milenković (University of Belgrade)H-Index: 2
#2Marija Rašević (University of Belgrade)
Last. Ana Protić (University of Belgrade)H-Index: 11
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Abstract null null Nowadays, method development is strongly focused on reducing time needed for method development and execution. This subject specially concerns gradient elution methods regarding the usual need for troubleshooting assistance with uncertain outcome during the method transfer from one laboratory to another. One of the main reasons for this situation is the dwell volume difference between HPLC systems. Therefore, the aim of this study was to propose a novel method development meth...
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#2Vinay Prathap (Biocon)
Last. Anurag S. Rathore (IITD: Indian Institute of Technology Delhi)H-Index: 33
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Process chromatography is commonly used for purification of therapeutic proteins. Most chromatography skids that are used in such operations utilize single ultraviolet (UV) absorbance for monitoring and quantification of protein content. While the signal from such UV measurement is linear with respect to protein concentration at low values of protein concentrations, as the concentration increases across an eluting product peak, it goes manifold over the linear range, resulting in saturation of t...
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#1Lisa Delahaye (UGent: Ghent University)H-Index: 4
Last. Christophe P. Stove (UGent: Ghent University)H-Index: 36
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Abstract null null Paracetamol (acetaminophen, APAP) is the most frequently used analgesic and antipyretic worldwide. Nonetheless, APAP induced hepatotoxicity is the most common cause of acute liver failure in the western world. This hepatotoxicity is related to the metabolism of APAP, via the formation of the electrophilic oxidation product N-acetyl-para-benzoquinone imine. To investigate differences in APAP metabolism in specific patient populations and to optimize dosing regimens, quantificat...
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#1Asami Matsumoto (Oita University)
#2Ken Shiraiwa (Oita University)H-Index: 1
Last. Hiroki Itoh (Oita University)H-Index: 17
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Abstract null null Pazopanib is widely used to treat renal cell carcinomas and soft tissue tumors in Japan. Although several reports demonstrated the usefulness of therapeutic drug monitoring (TDM) of pazopanib, those studies measured only total pazopanib concentration. For drugs with high protein binding rates such as pazopanib, measuring free concentrations may be clinically more useful than measuring total concentrations. In this study, we aimed to develop a high-throughput method for quantif...
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Top fields of study
Analytical chemistry
Detection limit
High-performance liquid chromatography
Chemistry
Chromatography
Quantitative analysis (chemistry)