Journal of Pharmaceutical and Biomedical Analysis
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Abstract The aim of the present study was to explore the feasibility of applying near-infrared (NIR) spectroscopy for the quantitative analysis of Δ9-tetrahydrocannabinol (THC) in cannabis products using handheld devices. A preliminary study was conducted on different physical forms (entire, ground and sieved) of cannabis inflorescences in order to evaluate the impact of sample homogeneity on THC content predictions. Since entire cannabis inflorescences represent the most common types of samples...
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
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Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
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#1Jinhui Lu (Southern Medical University)H-Index: 2
#2Ze Wu (Southern Medical University)H-Index: 1
Last. Tingting Li (Southern Medical University)H-Index: 10
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Abstract Brucellosis is a worldwide infectious zoonotic disease, posing severe threats to human health and social-economic development. By comparing with time-consuming, low sensitive and non-quantitative conventional serological methods, herein, protein G (prG) coupled with europium nanospheres (EuNPs) (detection probe) and highly purified Brucella lipopolysaccharide (LPS) (capture antigen) were used to develop a novel time-resolved fluorescence lateral flow immunoassay (TF-LFIA) for detecting ...
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#1Li Chen (OSU: Ohio State University)
#2Xiaowei Sun (OSU: Ohio State University)
Last. Jiangjiang Zhu (OSU: Ohio State University)H-Index: 19
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Abstract Short chain fatty acids (SCFAs), generated from microbial fermentation of dietary fibers, can regulate weight, appetite and energy homeostasis. Therefore, measuring SCFAs in fecal samples is important to understand the relationship between dietary patterns, gut microbial metabolism, and their impact on host metabolism homeostasis. However, due to the chemical complexity of fecal samples and the volatility of these SCFAs, the quantitative measurements of SCFAs remain challenging. In this...
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#1Tao Zhuang (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Guisen Zhang (HUST: Huazhong University of Science and Technology)H-Index: 2
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Abstract Sugammadex sodium is the first selective relaxant binding agent (SRBA) indicated for reversal of neuromuscular blockade induced by rocuronium or vecuronium during surgery. The chemical synthesis of sugammadex involved the nucleophilic substitution reaction between 6-per-deoxy-6-per-halo-γ-cyclodextrin and 3-mercaptopropionic acid under basic conditions. During the manufacture of sugammadex sodium, an unknown process-related impurity was observed in pilot batches in the range of 0.21–1.9...
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#1Zhenwei Lan (Guangdong Pharmaceutical University)H-Index: 2
#2Yifan Zhang (Guangdong Pharmaceutical University)
Last. Jiang Meng (Guangdong Pharmaceutical University)H-Index: 5
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Abstract It’s far from enough to describe the blood circulation promoting effect of Curcumae Rhizoma (CR), which is widely grown as a functional vegetable or spice in south and southeast Asian countries, and processed Curcumae Rhizoma (PCR), only by disclosing the content of a couple of relative compounds. In this study, the thrombin inhibitory effect as well as 2,2′-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-picrylhydrazyl (DPPH) free radical scavenging ability o...
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Abstract A novel, fast and sensitive LC-MS/MS method was developed and validated for the bioanalysis of the antiviral agent favipiravir (FAV); a promising candidate for treatment of SARS-CoV-2 (COVID-19) in human plasma using pyrazinamide as an internal standard (IS). Simple protein precipitation was adopted for plasma sample preparation using methanol. Chromatographic separation was accomplished on Eclipse plus C18 column (50 × 4.6 mm, 3.5 µm) using a mobile phase composed of methanol-0.2% acet...
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#1Xin Zheng (Peking Union Medical College Hospital)H-Index: 6
#2Huitao Gao (Peking Union Medical College Hospital)H-Index: 1
Last. Hongyun Wang (Peking Union Medical College Hospital)H-Index: 8
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Abstract Vorolanib is an oral tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR). A sensitive and specific LC-MS/MS assay was developed and fully validated for simultaneous quantification of vorolanib and its main metabolite X297 in human plasma. The two analytes were extracted from K2-EDTA plasma samples by protein precipitation (PP) with acetonitrile, and chromatographically separated on a C18 reverse-p...
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#1Ana Sheila de Queiroz Souza (Empresa Brasileira de Pesquisa Agropecuária)H-Index: 2
#1Ana Sheila de Queiroz Souza (UFC: Federal University of Ceará)H-Index: 1
Last. Luzia Kalyne Almeida Moreira Leal (UFC: Federal University of Ceará)H-Index: 22
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Abstract Hippeastrum elegans is an Amaryllidaceae species producing alkaloids with pharmaceutical potential including lycorine and galanthamine. Herein, we developed a non-targeted metabolomic study associated to chemometrics and biological evaluations to identify the H. elegans constituents that were able to reduce the human neutrophils proinflammatory mechanisms. The alkaloid fractions were extracted from bulbs cultivated for 15 months (m) and harvested in six harvest periods (5, 7, 9, 11, 13,...
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#1Patcharapan Suwannin (MU: Mahidol University)
#2Duangporn Polpanich (Thailand National Science and Technology Development Agency)H-Index: 9
Last. Tienrat Tangchaikeeree (MU: Mahidol University)H-Index: 4
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Malaria infection represents a major public health and economic issue that leads to morbidity and mortality globally. A highly effective and uncomplicated detection tool is required for malaria control in geographical hotspots of transmission. We developed a simple and more sensitive novel approach for the detection of the 18S rRNA gene of Plasmodium falciparum based on loop-mediated isothermal amplification (LAMP) and visualization using colorimetric, streptavidin-functionalized gold nanopartic...
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Top fields of study
Analytical chemistry
Detection limit
High-performance liquid chromatography
Chemistry
Chromatography
Quantitative analysis (chemistry)