Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum.

Published on Jun 2, 2021in Journal of Psychiatric Research3.745
· DOI :10.1016/J.JPSYCHIRES.2021.05.072
Abstract null null Background null Schizophrenia (SZ) and major depressive disorders (MDD) have been frequently linked to anatomical brain alterations. However, the relationship between brain pathology, inflammation and clinical symptoms in these disorders is still unclear. Thus, by applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL), we can now address main issues in psychiatric research and potentially offer innovative diagnostic tools toward better clinical characterizations and monitoring in both SZ and MDD. null null null Methods null NfL levels were measured in serum of 44 patients with SZ and in 41 patients with MDD applying single molecule array technology and compared to a healthy norm population. Main inflammatory markers (C- reactive protein, interleukins IL-6 and IL-10) were measured to define patients with inflammatory phenotype. The Digit Symbol Substitution Task (DSST) and the Letter-Number-Sequencing Task were performed to estimate cognitive function in both groups. null null null Results null NfL levels in MDD group (but not in SZ group) were significantly higher than reference values of healthy norm population. A higher than expected proportion of patients with NfL levels above age-specific cut-off values was observed in both SZ and MDD groups. No correlation was observed between NfL and inflammatory markers. A negative correlation between DSST and NfL-values was observed in patients with MDD. null null null Conclusions null Both SZ and MDD showed elevated serum levels of NfL, which were independent from inflammatory markers but associated with cognitive performance.
#1Yu-Li Liu (NHRI: National Health Research Institutes)H-Index: 14
#2Francesco Bavato (UZH: University of Zurich)H-Index: 1
Last. Boris B. Quednow (ETH Zurich)H-Index: 37
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OBJECTIVES Chronic and heavy ketamine use has been associated with persistent neurocognitive impairment and structural brain abnormalities. Blood levels of neurofilament light chain (NFL) was recently proposed as a measure of axonal integrity in several neuropsychiatric disorders. We aimed to characterize the axonal neurotoxicity of chronic ketamine use and its relationship to relevant clinical outcomes. METHODS We enrolled 65 treatment-seeking ketamine-dependent patients (55 males and 10 female...
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#1Maria A Di Biase (University of Melbourne)H-Index: 12
#2Andrew Zalesky (University of Melbourne)H-Index: 57
Last. Vanessa Cropley (Centre for Mental Health)H-Index: 24
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#1Flurin Cathomas (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
#2Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
Last. Philippe N. Tobler (UZH: University of Zurich)H-Index: 40
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One aspect of goal-directed behavior, which is known to be impaired in patients with schizophrenia (SZ), is balancing between exploiting a familiar choice with known reward value and exploring a lesser known, but potentially more rewarding option. Despite its relevance to several symptom domains of SZ, this has received little attention in SZ research. In addition, while there is increasing evidence that SZ is associated with chronic low-grade inflammation, few studies have investigated how this...
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#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 1
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
Last. Stefan Kaiser (Geneva College)H-Index: 28
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Abstract Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin and biopterin may link peripheral immune system activation and central neurotransmitter alterations. However, it is not fully established whether these alterations are transdiagnostic or disorder-specific and whether they are associated with reward-related psychopathologies. We investigated group...
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#1Barbora Srpova (First Faculty of Medicine, Charles University in Prague)H-Index: 5
#2Tomas Uher (First Faculty of Medicine, Charles University in Prague)H-Index: 16
Last. Dana Horakova (First Faculty of Medicine, Charles University in Prague)H-Index: 32
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#1Christian Barro (Brigham and Women's Hospital)H-Index: 1
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Last. Howard L. Weiner (Brigham and Women's Hospital)H-Index: 164
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Neuronal injury is a universal event that occurs in disease processes that affect both the central and peripheral nervous systems. A blood biomarker linked to neuronal injury would provide a critical measure to understand and treat neurologic diseases. Neurofilament light chain (NfL), a cytoskeletal protein expressed only in neurons, has emerged as such a biomarker. With the ability to quantify neuronal damage in blood, NfL is being applied to a wide range of neurologic conditions to investigate...
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#1Daniela Rodrigues-Amorim (University of Vigo)H-Index: 5
#2Tania Rivera-Baltanás (University of Vigo)H-Index: 7
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#1Laura S van Velzen (University of Melbourne)H-Index: 8
#2Sinead Kelly (Brigham and Women's Hospital)H-Index: 22
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Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Worki...
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#1Werner Surbeck (University of Liège)H-Index: 8
#2Jürgen Hänggi (UZH: University of Zurich)H-Index: 33
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