Unmasking latent thioesters under hydrophobic‐compatible conditions

Hydrophobic latent C‐terminal thioesters were converted into thioesters, and were also coupled with cysteine in one‐pot reactions, using conditions generally compatible with hydrophobic materials. The reaction conditions (ethanethiol and triethylamine in a mixture of DMF and THF) are compatible with acid‐labile protecting groups (Boc/t‐Bu) that are standard in Fmoc peptide...