Original paper
P2X3 receptors participate in purinergic inhibition of gastrointestinal smooth muscle
Abstract
The ATP analogue α,β-meATP is a potent relaxant of gastrointestinal smooth muscle, but its molecular target is uncertain inside the gut. α,β-meATP relaxed the carbachol-precontracted guinea-pig taenia coli in a concentration-dependent manner (EC50, 2.0 ± 0.1 μM). A luciferase-based assay confirmed that α,β-meATP solutions were minimally contaminated with ATP. α,β-meATP-evoked relaxations were inhibited by the competitive P2Y1 antagonist MRS2179...
Paper Details
Title
P2X3 receptors participate in purinergic inhibition of gastrointestinal smooth muscle
Published Date
Sep 1, 2021
Journal
Volume
234
Pages
102830 - 102830
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Notes
History