Autonomic Neuroscience: Basic and Clinical
Papers 3702
1 page of 371 pages (3,702 results)
#1Kanokwan Bunsawat (UofU: University of Utah)H-Index: 4
#2Stephen M. Ratchford (VA: United States Department of Veterans Affairs)H-Index: 5
Last. D. Walter Wray (VA: United States Department of Veterans Affairs)H-Index: 32
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Abstract null null Chronic sympathetic nervous system (SNS) overactivity, characteristic of heart failure (HF) with reduced ejection fraction (HFrEF), is associated with poor prognosis and contributes to increased mortality risk. Sacubitril-valsartan is a recently approved, first-in-class, angiotensin receptor neprilysin inhibitor (ARNI) drug that markedly reduces the risks of death from cardiovascular causes and hospitalization for HF in patients with HFrEF, but the physiological mechanisms und...
Abstract null null Background null Cardioneuroablation (CNA) has been recently proposed as a new therapy in patients with asystolic vasovagal syncope (VVS) caused by parasympathetic overactivity. null null null Objective null To assess the impact of CNA on the type of VV response during tilt testing (TT). null null null Methods null The study group consisted of 20 patients (7 males, mean age 38 ± 9). All patients had a history of syncope due to asystole and confirmed asystolic VVS at baseline TT...
#1Satish R. Raj (VUMC: Vanderbilt University Medical Center)H-Index: 51
#2Kate M. Bourne (U of C: University of Calgary)H-Index: 2
Last. Robert S. Sheldon (U of C: University of Calgary)H-Index: 58
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Abstract null null The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state of understanding of the pathophysiology of postural orthostatic tachycardia syndrome (POTS) and to identify knowledge gaps that must be addressed to enhance clinical care of POTS patients through research. This second (of two) articles summarizes current knowledge gaps, and outlines the clinical and research priorities for POTS. null POTS is a complex, multi-system, chronic ...
#1Alexander V. Gourine (UCL: University College London)H-Index: 50
#2K. Michael Spyer (UCL: University College London)H-Index: 22
Abstract null null This article is the authors' contribution to the tribute issue in honour of Geoffrey Burnstock, the founder of this journal and the field of purinergic signalling. We give a brief account of the results of experimental studies which at the beginning received valuable input from Geoff, who both directly and indirectly influenced our research undertaken over the last two decades. Research into the mechanisms controlling breathing identified ATP as the common mediator of the cent...
#2Jack Garland (Ministry of Health (New South Wales))H-Index: 8
Last. Rexson Tse (University of Auckland)H-Index: 13
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Abstract null null Sudden cardiac death (SCD) is the most common natural cause of death. The hypothesized mechanism of death is an arrhythmia precipitated by increased sympathetic outflow. The left stellate ganglion provides sympathetic innervation to the heart and plays a role in arrhythmogensis. We present a SCD with stellate ganglionitis in which the inflammatory cells were characterized. The case was 37-year-old man who died from ischemic and hypertensive heart disease. The left stellate gan...
#1Ramy Abdelnaby (RWTH Aachen University)H-Index: 1
#2Mohamed Elsayed (University of Ulm)H-Index: 1
Last. Andrea B. Maier (RWTH Aachen University)H-Index: 58
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Abstract null null Objectives null Vagus nerve (VN) has been suggested as one of the major routes of Parkinson's disease (PD) progression from enteric nervous system to brain. Therefore, the recent studies have investigated the VN structurally, with a focus on the changes in its size in PD patients using high-frequency ultrasonography. This systematic review and meta-analysis aims to evaluate VN size via ultrasound in PD compared to controls. null null null Methods null Totally, five studies wer...
Abstract null null This not an original publication or a current and up-to-date review of purinergic signalling and kidney function, but rather a tribute to Professor Geoffrey Burnstock, written as a short and personal memoir of our early collaborative work together on this topic: our beginnings and the subsequent journey we took with our many valued collaborators along the way.
Abstract null null The ATP analogue α,β-meATP is a potent relaxant of gastrointestinal smooth muscle, but its molecular target is uncertain inside the gut. α,β-meATP relaxed the carbachol-precontracted guinea-pig taenia coli in a concentration-dependent manner (EC50, 2.0 ± 0.1 μM). A luciferase-based assay confirmed that α,β-meATP solutions were minimally contaminated with ATP. α,β-meATP-evoked relaxations were inhibited by the competitive P2Y1 antagonist MRS2179 (pA2 = 5.36), but also by the co...
Abstract null null The high rates of mortality and disability resulting from intracerebral hemorrhage (ICH) are closely related to subsequent cardiac complications. The mechanisms underlying ICH-induced cardiac dysfunction are not fully understood. In this study, we investigated the role of sympathetic overactivity in mediating cardiac dysfunction post ICH in mice. Collagenase-injection ICH model was established in adult male C57BL/6J mice. Neurological function was subsequently evaluated at mul...
#1Steven Vernino (UTSW: University of Texas Southwestern Medical Center)H-Index: 49
#2Kate M. Bourne (U of C: University of Calgary)H-Index: 2
Last. Jeffrey R. BorisH-Index: 10
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Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by orthostatic intolerance with excessive heart rate increase without hypotension during upright posture. Patients often experience a constellation of other typical symptoms including fatigue, exercise intolerance and gastrointestinal distress. A typical patient with POTS is a female of child-bearing age, who often first displays symptoms in adolescence. The onset of POTS may be precipitated ...
Top fields of study
Autonomic nervous system
Heart rate
Diabetes mellitus