Autonomic Neuroscience: Basic and Clinical
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#1Emma N. Bardsley (University of Auckland)
#2Dylan K. Pen (University of Auckland)
Last. Julian F. R. Paton (University of Auckland)H-Index: 62
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Abstract Atmospheric oxygen concentrations rose markedly at several points in evolutionary history. Each of these increases was followed by an evolutionary leap in organismal complexity, and thus the cellular adaptions we see today have been shaped by the levels of oxygen within our atmosphere. In eukaryotic cells, oxygen is essential for the production of adenosine 5′-triphosphate (ATP) which is the ‘Universal Energy Currency’ of life. Aerobic organisms survived by evolving precise mechanisms f...
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#1Madeleine R. Di Natale (University of Melbourne)
#2Martin J. Stebbing (University of Melbourne)H-Index: 22
Last. John B. Furness (Florey Institute of Neuroscience and Mental Health)H-Index: 98
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Abstract This review traces the history of the discovery and subsequent understanding of smooth muscle cells and their motor innervation. Smooth muscle tissue is made up of thousands of very small, individual, electrically connected, muscle cells. Each axon that enters a smooth muscle tissue branches extensively to form a terminal arbour that comes close to hundreds of smooth muscle cells. The branches of the terminal arbour are varicose, and each varicosity, of which there can be thousands, con...
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Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor (α1-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α1-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Additionally, the association between α1-AR expression and activation with spontaneous and sympathetically maintained pain (SMP) induced by in...
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#1Alec L. E. Butenas (KSU: Kansas State University)H-Index: 3
#2Korynne S. Rollins (KSU: Kansas State University)H-Index: 4
Last. Steven W. Copp (KSU: Kansas State University)H-Index: 21
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Abstract The primary purpose of this investigation was to determine the role played by endoperoxide 4 receptors (EP4-R) and thromboxane A2 receptors (TxA2-R) during isolated dynamic muscle mechanoreflex activation in rats with heart failure with reduced ejection fraction (HF-rEF) and sham-operated healthy controls. We found that injection of the EP4-R antagonist L-161,982 (1 μg) into the arterial supply of the hindlimb had no effect on the peak pressor response to dynamic hindlimb muscle stretch...
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#1Fuyuki Tateno (Toho University)H-Index: 18
#2Ryuji Sakakibara (Toho University)H-Index: 42
Last. Megumi Sugiyama (Toho University)H-Index: 9
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Abstract Objectives Parkinson's disease (PD) is the most common degenerative cause of movement disorder, and autonomic dysfunction has been recognized in this disorder. PD patients' lower urinary tract (LUT) function is not established. We investigated LUT function in PD by single-photon emission computerized tomography (SPECT) imaging of the dopamine transporter with 123I-ioflupane and clinical-urodynamic observations. Patients and methods We retrospectively analyzed the cases of 30 patients di...
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#1Feng Hu (SJTU: Shanghai Jiao Tong University)
#1Feng Hu (Peking Union Medical College)H-Index: 4
Last. Yan Yao (Peking Union Medical College)H-Index: 50
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Abstract Aims Cardioneuroablation is an emerging and promising therapy to treat vasovagal syncope (VVS). The aim of this study was to assess the characteristics of vagal response (VR), heart rate (HR), and blood pressure (BP) during cardioneuroablation with different sequences of ganglionated plexus (GPs) catheter ablation and clarify the regulatory mechanism of cardiac GPs of the left atrium. Methods A total of 28 patients with VVS who underwent cardioneuroablation were prospectively enrolled a...
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Abstract Vagal afferents form the primary gut-to-brain neural axis, communicating signals that regulate gastrointestinal (GI) function and promote satiation, appetition and reward. Neurotrophin-4 (NT-4) is essential for the survival of vagal smooth muscle afferents of the small intestine, but not the stomach. Here we took advantage of near-complete labeling of GI vagal mucosal afferents in Nav1.8cre-Rosa26tdTomato transgenic mice to determine whether these afferents depend on NT-4 for survival. ...
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#1Helen Eftekhari (University Hospitals Coventry and Warwickshire NHS Trust)H-Index: 1
Last. Sajad Hayat (Hamad Medical Corporation)
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Abstract POTS is under diagnosed with an estimated prevalence of 0.2%. North American and Australian researchers, as well as patient groups have called for more research into POTS. However, there has been no comprehensive appraisal of the current POTS evidence base. Aim To map the POTS evidence base. Methods Two reviewers systematically searched 12 databases until July 1st 2019 using the search term “Postural Tachycardia Syndrome” (n = 7280) and categorised the literature. Inclusion criteria inc...
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#1Benedito H. Machado (USP: University of São Paulo)H-Index: 23
#2Julian F. R. Paton (USP: University of São Paulo)H-Index: 62
Abstract We have considered some of the available evidence to account for the impact of SARS-CoV on the regulatory control of the autonomic nervous and respiratory systems. Apart from stimulating general interest in the subject, our hope was to provide putative explanations for some of the patients' symptoms based on described physiological and pathophysiological mechanisms seen in other diseases. Herein, we have focused on the carotid bodies. In this hypothetical viewpoint, we have discussed th...
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#1Louiza Belkacemi (College of Osteopathic Medicine of the Pacific)H-Index: 1
#2Weixia Zhong (College of Osteopathic Medicine of the Pacific)H-Index: 11
Last. Nissar A. Darmani (College of Osteopathic Medicine of the Pacific)H-Index: 18
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Abstract With its five receptor subtypes (D1–5), dopamine is implicated in a myriad of neurological illnesses. Dopamine D2 receptor-based agonist therapy evokes nausea and vomiting. The signaling mechanisms by which dopamine D2 receptors evoke vomiting remains unknown. Phosphatidylinositol 3-kinases (PI3K)- and protein kinase C (PKC)-related signaling cascades stimulate vomiting post-injection of various emetogens in emetically competent animals. This study investigated potential mechanisms invo...
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Endocrinology
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