Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure-Results From the MyoVasc Study

Published on Jun 16, 2021in Frontiers in Cardiovascular Medicine6.05
· DOI :10.3389/FCVM.2021.682521
Felix Müller1
Estimated H-index: 1
Highlights •HFpEF is a condition predominantly of postmenopausal women. •Menopause-related E2 decline might contribute to HFpEF onset. •E2 regulates several pathways involved in the pathogenesis of HFpEF. •Targets for the prevention and therapy of HFpEF are necessary.
#1Annamaria De Bellis (UniTS: University of Trieste)H-Index: 1
#2Giulia De Angelis (UniTS: University of Trieste)H-Index: 5
Last. Gianfranco Sinagra (UniTS: University of Trieste)H-Index: 69
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Cardiovascular diseases show many sex-related differences in prevalence, etiology, phenotype expression, and outcomes. Complex molecular mechanisms underlie this diverse pathological manifestation, from sex-determined differential gene expression to sex hormones interaction with their specific receptors in different tissues. More recently, differential non-coding RNAs regulation also turned out to be an involved mechanism. This review focuses on sex impact on the various heart failure syndromes,...
#1Carolyn S.P. LamH-Index: 80
#2Clare ArnottH-Index: 14
Last. Adriaan A. VoorsH-Index: 118
view all 10 authors...
The overall lifetime risk of heart failure (HF) is similar between men and women, however, there are marked sex differences in the landscape of this condition that are both important and under-recognized. Men are predisposed to HF with reduced ejection fraction (HFrEF), whereas women predominate in HF with preserved ejection fraction (HFpEF). Sex differences are also notable in the penetrance of genetic cardiomyopathies, risk factors, e.g. breast cancer which may be associated with cancer treatm...
#1Ariane A Sickinghe (UU: Utrecht University)H-Index: 2
#2Suzanne J.A. Korporaal (UU: Utrecht University)H-Index: 19
Last. Elise L. Kessler (UU: Utrecht University)H-Index: 6
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Heart failure with preserved ejection fraction (HFpEF) is a syndrome involving microvascular dysfunction. No treatment is available yet and as the HFpEF patient group is expanding due to the ageing population, more knowledge on dysfunction of the cardiac microvasculature is required. Endothelial dysfunction, impaired angiogenesis, (perivascular) fibrosis and the pruning of capillaries (rarefaction) may all contribute to microvascular dysfunction in the heart and other organs, e.g. the kidneys. T...
#1Shan Luo (HKU: University of Hong Kong)H-Index: 7
#2Shiu Lun Au Yeung (HKU: University of Hong Kong)H-Index: 18
Last. C. Mary Schooling (CUNY: City University of New York)H-Index: 35
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Abstract Objective To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. Design Two sample mendelian randomisation study using genetic variants as instrumental variables, randomly allocated at conception, to infer causality as additional randomised evidence. Setting Reduction by Dutasteride of Prostate Cancer Events (REDUCE) randomised controlled trial, UK Biobank, and CARDIoGRAMplusC4D 1000 Genomes based genome wide associat...
#1Petra Zubin Maslov (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 2
#2Jin Kyung Kim (UCI: University of California, Irvine)H-Index: 13
Last. Jagat Narula (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 4
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Abstract Post-menopausal women exhibit an exponential increase in the incidence of heart failure with preserved ejection fraction compared with men of the same age, which indicates a potential role of hormonal changes in subclinical and clinical diastolic dysfunction. This paper reviews the preclinical evidence that demonstrates the involvement of estrogen in many regulatory molecular pathways of cardiac diastolic function and the clinical data that investigates the effect of estrogen on diastol...
#1Daniel M. Johnson (University of Birmingham)H-Index: 34
#2Alessandro Mugelli (UniFI: University of Florence)H-Index: 51
Last. Elisabetta Cerbai (UniFI: University of Florence)H-Index: 51
view all 3 authors...
#1Anna L Beale (Monash University)H-Index: 2
#2Philippe Meyer (Monash University)H-Index: 1
Last. David M. Kaye (Alfred Hospital)H-Index: 98
view all 5 authors...
Consistent epidemiological data demonstrate that patients with heart failure with preserved ejection fraction (HFpEF) are more likely to be women than men. Exploring mechanisms behind this sex difference in heart failure epidemiology may enrich the understanding of underlying HFpEF pathophysiology and phenotypes, with the ultimate goal of identifying therapeutic approaches for the broader HFpEF population. In this review we evaluate the influence of sex on the key domains of cardiac structure an...
#1Heidi D. MorettiH-Index: 1
#2Vincent J Colucci (UM: University of Montana)H-Index: 8
Last. Bradley D. BerryH-Index: 2
view all 3 authors...
Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility. Vitamin D deficiency is associated with morbidity and mortality in HF patients. The objective of this study was to determine if vitamin D3 at a comparatively high dose would replete 25-hydroxyvitamin D (25(OH)D) stores, improve BNP, PTH, cardiopulmonary function, reduce inflammatory markers, and improve quality of life (...
#1Gianluigi SavareseH-Index: 32
#2Lars H. Lund (KI: Karolinska Institutet)H-Index: 4
Heart failure (HF) is a global pandemic affecting at least 26 million people worldwide and is increasing in prevalence. HF health expenditures are considerable and will increase dramatically with an ageing population. Despite the significant advances in therapies and prevention, mortality and morbidity are still high and quality of life poor. The prevalence, incidence, mortality and morbidity rates reported show geographic variations, depending on the different aetiologies and clinical character...
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