Farnesoid X Receptor Regulates Immune Cell Activation and Recruitment to the Lung following Exposure of Mice to Nitrogen Mustard

Nitrogen mustard (NM) is a cytotoxic vesicant known to cause acute lung injury which progresses to fibrosis. This is accompanied by a robust inflammatory cell response, including activation of resident alveolar macrophages and an accumulation of bone marrow-derived monocytes in the lung, which develop into pro-inflammatory/cytotoxic M1 macrophages and anti-inflammatory/pro-fibrotic M2 macrophages. Farnesoid X receptor (FXR) is a bile-acid...