Original paper
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
Abstract
The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the aggressive transformation of cells is unclear. Here we use integrative epigenomic profiling of invasive fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and from mouse...
Paper Details
Title
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
Published Date
Jun 15, 2021
Journal
Volume
12
Issue
1
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Notes
History