Antioxidant product analysis of Folium Hibisci Mutabilis

Published on Jul 1, 2021in Journal of Saudi Chemical Society3.517
· DOI :10.1016/J.JSCS.2021.101272
#1Baitao Ma (Peking Union Medical College Hospital)H-Index: 4
#2Xuebin Wang (Capital Medical University)
Last. Changwei Liu (Peking Union Medical College Hospital)H-Index: 14
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Cigarette smoke (CS) exposure is a risk factor for dyslipidemia and atherosclerosis. Reduced expression of low‑density lipoprotein receptor (LDLR) in hepatocytes may be one of the underlying mechanisms for these disorders. The aim of the present study was to investigate the molecular mechanism underlying the regulatory effect of CS extract (CSE) on proprotein convertase subtilisin/kexin type 9 (PCSK9) and low LDLR expression in HepG2 cells. PCSK9 and LDLR mRNA and protein expression levels in He...
1 CitationsSource
#1Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 8
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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The search for safe and effective ferroptosis-inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin-induced ferroptosis in bone marrow-derived mesenchymal stem cells (bmMSCs). To determine the mechanism, geraniin was further analyzed using UV-vis spectra and several colorimetric assays, where its IC50 values were always much lower than that of the Trolox positive cont...
1 CitationsSource
#1Shan Han (Sichuan Agricultural University)H-Index: 4
#1Shan Han (Sichuan Agricultural University)H-Index: 2
Last. Chunlin YangH-Index: 1
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Cotton rose (Hibiscus mutabilis Linn.) is a deciduous shrub native to China. It has been widely cultivated in many provinces in China for its ornamental and ecological value (Shang et al., 2020). In May 2017, an unknown leaf spot symptom was first observed on H. mutabilis at the Chengdu Campus of Sichuan Agricultural University (30°42'31″ N, 103°51'28″ E). The disease occurred from May to September with approximately 81% incidence by field sample survey of 300 plants in Chengdu Greenway. The sym...
1 CitationsSource
#1Helen L. WrightH-Index: 16
#2Max LyonH-Index: 2
Last. Steven W. EdwardsH-Index: 64
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Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints. Neutrophils are believed to play an important role in both the initiation and progression of RA, and large numbers of activated neutrophils are found within both synovial fluid (SF) and synovial tissue from RA joints. In this study we analyzed paired blood and SF neutrophils from patients with severe, active RA (DAS28g5.1, n=3) using RNA-seq. 772 genes were significantly different between blood and SF neutrop...
3 CitationsSource
#1Wan-Feng Liang (Yanbian University)H-Index: 1
#2Yi-Xi Gong (Yanbian University)H-Index: 2
Last. Hu-Nan SunH-Index: 10
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BACKGROUND/AIM Curcumin is a polyphenol that exerts a variety of pharmacological activities and plays an anti-cancer role in many cancer cells. It was recently reported that gasdermin E (GSDME) is involved in the progression of pyroptosis. MATERIALS AND METHODS HepG2 cells were treated with various concentrations of curcumin and cell viability was examined using MTT assay, apoptosis was analysed using flow cytometry, reactive oxygen species (ROS) levels using dihydroethidium, LDH release using a...
5 CitationsSource
#1Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 1
#2Tianyu Luo (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 1
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Gallic acid is an active phenolic acid widely distributed in plants, and there is compelling evidence to prove its anti-inflammatory effects. NLRP3 inflammasome dysregulation is closely linked to many inflammatory diseases. However, how gallic acid affects the NLRP3 inflammasome remains unclear. Therefore, in the present study, we investigated the mechanisms underlying the effects of gallic acid on the NLRP3 inflammasome and pyroptosis, as well as its effect on gouty arthritis in mice. The resul...
5 CitationsSource
#1Yan ZhuH-Index: 1
#2Zhang HaixinH-Index: 1
Last. Chen LiangH-Index: 2
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This study evaluated the effect of four peptides, VLP, LLP, LL, and LL from pea on regulating glucose metabolism and antioxidant through IRS-1/PI3K/AKT and p38MAPK signal pathway in IR-HepG2 cell induced by 10-6 M insulin. The genes expression of PEPCK, G6Pase, GLUT2, and IRS-1 and proteins of IRS-1, p(Ser307)-IRS-1, AKT, p(Ser473)-AKT, p38MAPK, and p-p38MAPK were determined by RT-PCR and western blotting, respectively. Results show that they displayed highly potent on stimulation glucose metabo...
2 CitationsSource
#1Ikuo NakanishiH-Index: 23
#2Yoshimi ShojiH-Index: 5
Last. Shunichi FukuzumiH-Index: 129
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A large kinetic isotope effect (KIE, kH/kD) of 12.8 was observed for the hydrogen-transfer reaction from ascorbic acid to 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO●) in a phosphate buffer solution (0.05 M, pH/pD 7.0) at 298 K. The isotopic difference in the activation energies (6.8 kJ mol−1) determined from the temperature dependence of the KIE suggests that quantum mechanical tunneling may partly play a role in the reaction, although the isotopic ratio of the Arrhenius prefac...
6 CitationsSource
#1Alberto Sola-Leyva (UGR: University of Granada)H-Index: 5
#2Ylenia Jabalera (UGR: University of Granada)H-Index: 6
Last. Concepcion Jimenez-Lopez (UGR: University of Granada)H-Index: 18
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Recent studies have shown the potential of magnetic hyperthermia in cancer treatments. However, the underlying mechanisms involved have not been yet fully described. In particular, the cell death related to magnetic hyperthermia observed in cultures incubated with low concentration of magnetic nanoparticles and under a low intensity alternating magnetic field, in which a macroscopic temperature rise is not observed, is still not understood. In the present study, we investigate the production of ...
5 CitationsSource
#1Xianwang Zhang (CAS: Chinese Academy of Sciences)
#2Jialong Jie (BNU: Beijing Normal University)H-Index: 4
Last. Hongmei Su (BNU: Beijing Normal University)H-Index: 18
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Proton transfer is regarded as a fundamental process in chemical reactions of DNA molecules, and continues to be an active research theme due to the connection with charge transport and oxidation damage of DNA. For guanine radical cation (G•+) derived from one-electron oxidation, experiments suggest a facile proton transfer within the G•+: C base pair, and a rapid deprotonation from N1 in free base or single-strand DNA. To address the deprotonation mechanism, we perform a thorough investigation ...
4 CitationsSource
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