Dongfeng Chen
Guangzhou University of Chinese Medicine
AdductmicroRNACellChemistryApoptosisMesenchymal stem cellHydroxyl radicalAntioxidantMTT assayABTSDPPHStem cellTransplantationElectrospray ionizationBiochemistrySignal transductionStereochemistryBiologyCell biologyPharmacology
125Publications
22H-index
1,634Citations
Publications 125
Newest
#1Zifeng Huang (Guangzhou University of Chinese Medicine)
Last. Meiling ZhuH-Index: 3
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Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson’s disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxid...
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#1Xin-Rong LiH-Index: 2
#2Wenwen SiH-Index: 3
Last. Meiling ZhuH-Index: 3
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Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). In a previous study, the authors demonstrated that ferritin heavy chain 1 (FTH1) inhibited ferroptosis in a model of 6‑hydroxydopamine (6‑OHDA)‑induced PD. However, whether and how microRNAs (miRNAs/miRs) modulate FTH1 in PD ferroptosis is not yet well understood. In the present study, in vivo and in vitro models of PD induced by 6‑OHDA were establishe...
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#2Yichun Ji (Guangzhou University of Chinese Medicine)
Last. Weihong KuangH-Index: 3
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Abstract In 1954, the term "probiotics" was coined by Ferdinand Vergin in his article. Although there are many clinical reports on the use of pro/synbiotics and other microbial preparations to prevent postoperative infections and related complications in patients with Colorectal cancer (CRC), their effectiveness remains divided. Therefore, we collected relevant high-quality randomized controlled trial (RCT) studies and conducted systematic review and meta-analysis. We electronically searched onl...
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#1Ziwei Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jianping Dou (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
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MicroRNAs (miRNAs) participate in the repair of skin trauma. Our previous study indicated that loureirin A promoted hair follicle stem cells (HFSCs) to repair skin epidermis. However, the mechanism of miRNA-mediated regulation of loureirin A-induced HFSC differentiation remained to be explored. In the present study, HFSCs from rat vibrissa were identified by immunofluorescence in vitro. Microarray and quantitative real time polymerase chain reaction (qRT-PCR) analyses demonstrated that miR-203a-...
1 CitationsSource
#1Jun-Lang Zhu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Wang Bin (Guangzhou University of Chinese Medicine)H-Index: 4
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Abstract Background Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only a small number of implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration of MSCs in injured tissue. Methods The migration and osteogenesis of MSCs were assessed by transwell assay and Alizarin Red S staining. Levels of gene and protein expressio...
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#1Ban ChenH-Index: 6
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng ChenH-Index: 22
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Synthetic arylamines and dietary phytophenolics could inhibit ferroptosis, a recently discovered regulated cell death process. However, no study indicates whether their inhibitory mechanisms are inherently different. Herein, the ferroptosis-inhibitory mechanisms of selected ferrostatin-1 (Fer-1) and two dietary stilbenes (piceatannol and astringin) were compared. Cellular assays suggested that the ferroptosis-inhibitory and electron-transfer potential levels decreased as follows: Fer-1 >> piceat...
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#1Yangping Liu (Guangzhou University of Chinese Medicine)H-Index: 2
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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#1Ban Chen (Guangzhou University of Chinese Medicine)H-Index: 6
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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The search for safe and effective ferroptosis-inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin-induced ferroptosis in bone marrow-derived mesenchymal stem cells (bmMSCs). To determine the mechanism, geraniin was further analyzed using UV-vis spectra and several colorimetric assays, where its IC50 values were always much lower than that of the Trolox positive cont...
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#1Yuqing Lin (Guangzhou University of Chinese Medicine)H-Index: 1
#2Tianyu Luo (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Hao Pan (Guangzhou University of Chinese Medicine)H-Index: 1
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Gallic acid is an active phenolic acid widely distributed in plants, and there is compelling evidence to prove its anti-inflammatory effects. NLRP3 inflammasome dysregulation is closely linked to many inflammatory diseases. However, how gallic acid affects the NLRP3 inflammasome remains unclear. Therefore, in the present study, we investigated the mechanisms underlying the effects of gallic acid on the NLRP3 inflammasome and pyroptosis, as well as its effect on gouty arthritis in mice. The resul...
1 CitationsSource
#1Ye Tian (Guangzhou University of Chinese Medicine)H-Index: 3
#2Juan Lu (Southern Medical University)H-Index: 1
Last. Meiling Zhu (Guangzhou University of Chinese Medicine)H-Index: 3
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Parkinson’s disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons associated with dysregulation of iron homeostasis in the brain. Ferroptosis is an iron-dependent cell death process that serves as a significant regulatory mechanism in PD. However, its underlying mechanisms are not yet fully understood. By performing RNA sequencing analysis, we found that the main iron storage protein ferritin heavy chain 1 (FTH1) is differentially expressed in the rat...
5 CitationsSource