Dual role of p62/SQSTM1 in acetaminophen‐induced early acute injury and late recovery in mice

Background Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the U.S. and many other countries. APAP induces hepatocyte necrosis through sequential events that include the formation of a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), the formation of APAP-adducts with cellular and mitochondrial proteins that trigger mitochondrial dysfunction and necrotic cell death. We...