Role of an ABCB1 1930_1931del TC gene mutation in a temporal cluster of macrocyclic lactone–induced neurologic toxicosis in cats associated with products labeled for companion animal use

OBJECTIVE To determine whether ABCB1 1930_1931del TC predisposed cats to macrocyclic-lactone toxicosis and the frequency of the ABCB1 1930_1931del TC gene mutation in banked feline DNA samples. SAMPLE DNA samples from 5 cats presented for neurologic clinical signs presumed to be caused by exposure to macrocyclic lactones and 1,006 banked feline DNA samples. PROCEDURES The medical history pertaining to 5 cats was obtained from veterinarians who...