Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us
Abstract
Cancer is the dysregulated proliferation of cells caused by acquired mutations in key driver genes. The most frequently mutated driver genes promote tumorigenesis in various organisms, cell types, and genetic backgrounds. However, recent cancer genomics studies also point to the existence of context-dependent driver gene functions, where specific mutations occur predominately or even exclusively in certain tumor types or genetic backgrounds....
Paper Details
Title
Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us
Published Date
Sep 1, 2021
Journal
Volume
7
Issue
9
Pages
823 - 836
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Notes
History