Whole genome, exon mutation and transcriptomic profiling of acute myeloid leukemia: A case report

The present study aimed to observe previously unidentified gene mutation and expression profiles associated with acute myeloid leukemia (AML) at the individual level, based on the blood samples of a father‑son pair. Genomic DNA and RNA samples from blood serum were collected. Whole‑genome sequencing (WGS) and whole‑exome sequencing (WES), as well as mRNA sequencing of the son, were performed. For the father's sample, a total of 3,897,164 single...