Integrin α4β1 is required for IL ‐1α‐ and Nrf2‐dependent, Cox‐2 induction in fibroblasts, supporting a mechanism that suppresses α‐SMA expression
Abstract
Growth and repair processes, both normal and pathological, require reciprocal interactions between cells and their microenvironment. Integrins are bidirectional, cell surface receptors that transduce mechanical and chemical signals to and from the extracellular matrix. We recently reported that keratinocyte α3β1 is required for interleukin (IL)‐1α secretion. Importantly, IL‐1α regulates fibroblast Cox‐2 expression and prostaglandin E2 (PGE 2 )...
Paper Details
Title
Integrin α4β1 is required for IL ‐1α‐ and Nrf2‐dependent, Cox‐2 induction in fibroblasts, supporting a mechanism that suppresses α‐SMA expression
Published Date
May 28, 2021
Volume
29
Issue
4
Pages
597 - 601
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