Wound Repair and Regeneration
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#1Mugdha Sawant (University of Cologne)H-Index: 5
#2Boris Hinz (U of T: University of Toronto)H-Index: 65
Last. Ronen Schuster (U of T: University of Toronto)H-Index: 7
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Our skin is continuously exposed to mechanical challenge, including shear, stretch, and compression. The extracellular matrix of the dermis is perfectly suited to resist these challenges and maintain integrity of normal skin even upon large strains. Fibroblasts are the key cells that interpret mechanical and chemical cues in their environment to turnover matrix and maintain homeostasis in the skin of healthy adults. Upon tissue injury, fibroblasts and an exclusive selection of other cells become...
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#1Alexis Desmoulière (University of Limoges)H-Index: 49
#2Boris Hinz (U of T: University of Toronto)H-Index: 65
The term myofibroblast has been introduced 50 years ago by Gabbiani and coworkers in two subsequent studies that characterized these enigmatic cells morphologically and functionally. This editorial provides a brief historical overview on the discoverer and the subject to introduce a theme issue on myofibroblasts that celebrates this important discovery. Owing to their central roles in promoting physiological wound healing but also excessive scarring of skin and internal organs, understanding myo...
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#1Alberto ZulloH-Index: 13
#2Francesco ManciniH-Index: 50
Last. Werner Klingler (TUM: Technische Universität München)
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Fibrotic diseases are still a serious concern for public health, due to their high prevalence, complex etiology, and lack of successful treatments. Fibrosis consists of excessive accumulation of extracellular matrix components. As a result, the structure and function of tissues are impaired, thus potentially leading to organ failure and death in several chronic diseases. Myofibroblasts represent the principal cellular mediators of fibrosis, due to their extracellular matrix producing activity, a...
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Heart disease with attendant cardiac fibrosis kills more patients in developed countries than any other disease, including cancer. We highlight the recent literature on factors that activate and also deactivate cardiac fibroblasts. Activation of cardiac fibroblasts results in myofibroblasts phenotype which incorporates aSMA to stress fibres, express ED-A fibronectin, elevated PDGFRα and are hypersecretory ECM components. These cells facilitate both acute wound healing (infarct site) and chronic ...
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#1Thomas E SerenaH-Index: 18
#2Simon W. BayliffH-Index: 1
Last. Marissa J. CarterH-Index: 17
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Millions worldwide suffer from chronic wounds challenging clinicians and burdening healthcare systems. Bacteria impede wound healing; however, the diagnosis of excessive bacterial burden or infection is elusive. Clinical signs and symptoms of infection are inaccurate and unreliable. This trial evaluated a novel, point-of-care, lateral flow diagnostic designed to detect virulence factors released by the most common bacteria found in chronic wounds. A multicentre prospective cohort clinical trial ...
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#1Rui Zheng (Albany Medical College)H-Index: 3
#2Scott Varney (Albany Medical College)H-Index: 4
Last. Livingston Van De Water (Albany Medical College)H-Index: 17
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Growth and repair processes, both normal and pathological, require reciprocal interactions between cells and their microenvironment. Integrins are bidirectional, cell surface receptors that transduce mechanical and chemical signals to and from the extracellular matrix. We recently reported that keratinocyte α3β1 is required for interleukin (IL)-1α secretion. Importantly, IL-1α regulates fibroblast Cox-2 expression and prostaglandin E2 (PGE2 ) secretion, thereby linking keratinocyte integrin func...
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#1Ambika Agrawal (U of A: University of Alberta)H-Index: 1
#2Jie Ding (U of A: University of Alberta)H-Index: 21
Last. Edward E. Tredget (U of A: University of Alberta)H-Index: 70
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Hypertrophic scars (HTS) are a common complication following burn injuries with prolonged inflammation. They do not respond well to current treatment options including mechanical, biomolecular and surgical therapies. Toll-like receptor (TLR) 2 and 4 respond to microbes and damaged endogenous ligands to trigger pro-inflammatory pathways, and they are expressed more in HTS fibroblasts compared to normal skin fibroblasts. TLR2 responds to microbial lipoteichoic acid (LTA) while TLR4 responds to mic...
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#1Anca Maglaviceanu (UHN: University Health Network)
#2Brian Wu (UHN: University Health Network)H-Index: 18
Last. Mohit Kapoor (UHN: University Health Network)H-Index: 26
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The synovial membrane undergoes a variety of structural changes throughout the pathogenesis of osteoarthritis (OA), including the development of fibrosis. Fibroblast-like synoviocytes (FLS) are a heterogenous cell population of the synovium that are suggested to drive the fibrotic response, but the exact endogenous mechanisms associated with their activation in OA remain unclear. Once activated, FLS are suggested to acquire a myofibroblast-like phenotype that drives fibrogenesis through excessiv...
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#1Amy O'Regan (Mater Misericordiae University Hospital)
#2Colm O'Brien (Mater Misericordiae University Hospital)H-Index: 44
Last. Sarah Eivers (Mater Misericordiae University Hospital)
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Glaucoma is a common progressive optic neuropathy that results in visual field defects and can lead to irreversible blindness. The pathophysiology of glaucoma involves dysregulated extracellular matrix remodelling in both the trabecular meshwork in the anterior chamber and in the lamina cribrosa of the optic nerve head. Fibrosis in these regions leads to raised intraocular pressure and retinal ganglion cell degeneration, respectively. Lysophosphatidic acid (LPA) is a bioactive lipid mediator whi...
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#1P. Monika (RIT: M. S. Ramaiah Institute of Technology)H-Index: 1
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Fibroblasts and Myofibroblasts play a myriad of important roles in human tissue function, especially in wound repair and healing. Among all cells, fibroblasts are group of cells that decide the status of wound as they maintain tissue homeostasis. Currently, the increase in the deleterious effects of chronic wound and their morbidity rate has necessitated the need to understand the influence of fibroblasts and myofibroblasts, which chiefly originate locally from tissue-resident fibroblasts to add...
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Top fields of study
Anatomy
Surgery
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Wound healing
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