Wound Repair and Regeneration
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#1Xiaohao Xu (Changchun University)H-Index: 8
#2Guang Sun (Changchun University)
Last. Jiang Rui (Changchun University)H-Index: 1
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Prolonged skin exposure to ultraviolet radiation can lead to development of several acute and chronic diseases, with UVA exposure considered a primary cause of dermal photodamage. We prepared a wild ginseng adventitious root extract (ARE) that could alleviate UVA irradiation-induced NIH-3T3 cell viability decline. After employing a series of purification methods to isolate main active components of ARE, adventitious root protein mixture (ARP) was identified then tested for protective effects aga...
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Chronic wounds caused by underlying physiological causes such as diabetic wounds, pressure ulcers, venous leg ulcers and infected wounds affect a significant portion of the population. In order to treat chronic wounds, a strong debridement, removal of necrotic tissue, elimination of infection and stimulation of granulation tissue are required. Maggot debridement therapy (MDT), which is an alternative treatment method based on history, has been used quite widely. MDT is an efficient, simple, cost...
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#1Helen Williams (USYD: University of Sydney)H-Index: 8
#1Helen Williams (Westmead Hospital)
Last. Heather J. Medbury (USYD: University of Sydney)H-Index: 12
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Hypertrophic scars (HTS) remain a common outcome of burn injury, particularly in children. They can arise from variations in the wound healing stages, such as an excessive inflammatory response or inefficient remodelling. Of the cells contributing to these healing stages, macrophages and fibrocytes are crucial. Specifically, the inflammatory phase is dominated by M1 macrophages, the proliferation/remodelling stages by M2 macrophages, and scar tissue contains numerous fibrocytes. As the progenito...
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#1Jane Thinggaard Knudsen (OUH: Odense University Hospital)
#2Charlotte W. Johansen (OUH: Odense University Hospital)
Last. Henrik Eshøj (OUH: Odense University Hospital)H-Index: 5
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Hard to heal (HTH) wounds often result in a prolonged and painful healing process that affects different dimensions of patients' quality of life. Currently, there is no Danish patient-reported instrument to help professionals and patients identify and measure these different aspects of quality of life. Wound-quality of life (Wound-QoL) is a German 17-item questionnaire measuring dimensions of wound-specific quality of life. The aim was to translate and cross-culturally adapt the Wound-QoL into D...
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Patients with a diabetic foot ulcer (DFU) suffer disabilities and are at increased risk for lower extremity amputation. Current standard of care includes debridement, topical antibiotics, and weight off-loading-still resulting in low rates of healing. Previous small-scale research has indicated that repeated remote ischemic conditioning (rRIC) is a novel modality that delivers significantly higher DFU healing rates. This proof-of-concept study was performed to expand the research on the utility ...
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#1Yaron Shoham (BGU: Ben-Gurion University of the Negev)H-Index: 10
Last. Avshalom Shalom (Meir Medical Center)
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Chronic wounds are estimated to affect over 6 million people annually in the United States with an estimated annual cost of $25 billion. Debridement represents a key step in their management and is considered a basic necessity to induce the functional process of tissue repair. However, there is an unmet need for an efficient rapid acting non-surgical debridement agent. Bromelain-based enzymatic debridement has been proven to provide an effective, selective and safe non-surgical debridement in de...
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#1Rou Wan (NU: Northwestern University)H-Index: 1
#2Joshua P. Weissman (NU: Northwestern University)
Last. Robert D. Galiano (NU: Northwestern University)H-Index: 45
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Diabetes is a systemic disease in which the body cannot regulate the amount of sugar, namely glucose, in the blood. High glucose toxicity has been implicated in the dysfunction of diabetic wound healing, following insufficient production (Type 1) or inadequate usage (Type 2) of insulin. Chronic non-healing diabetic wounds are one of the major complications of both types of diabetes, which are serious concerns for public health and can impact the life quality of patients significantly. In general...
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#1Helen L. Brown (Cardiff University)H-Index: 6
#2Aled Clayton (Cardiff University)H-Index: 40
Last. Phil Stephens (Cardiff University)H-Index: 5
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Chronic wounds are a significant global problem with an increasing economic and patient welfare impact. How wounds move from an acute to chronic, non-healing, state is not well understood although it is likely that it is driven by a poorly regulated local inflammatory state. Opportunistic pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa are well known to stimulate a pro-inflammatory response and so their presence may further drive chronicity. Studies have demonstrated that host...
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#1Rebeca de Oliveira Camargo (UM: University of Manitoba)H-Index: 1
Last. Ian M.C. Dixon (UM: University of Manitoba)H-Index: 46
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Heart disease with attendant cardiac fibrosis kills more patients in developed countries than any other disease, including cancer. We highlight the recent literature on factors that activate and also deactivate cardiac fibroblasts. Activation of cardiac fibroblasts results in myofibroblasts phenotype which incorporates aSMA to stress fibres, express ED-A fibronectin, elevated PDGFRα and are hypersecretory ECM components. These cells facilitate both acute wound healing (infarct site) and chronic ...
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#1Inge Spronk (EUR: Erasmus University Rotterdam)H-Index: 11
Last. Anouk Pijpe (VU: VU University Amsterdam)H-Index: 12
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Long-term scar formation is an important adverse consequence in children with burns, however, information regarding scar quality in the long-term is lacking. Therefore, we evaluated scar quality and its predictors in children with burns 5-7 years after injury. Parents of children with mild/intermediate burns (≤10% total body surface area burned), and of children with severe burns (>10% burned) completed the patient scale of the Patient and Observer Scar Assessment Scale (POSAS 2.0) for their chi...
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Top fields of study
Anatomy
Surgery
Pathology
Wound healing
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Biology