Review paper
Fibrosis: Sirtuins at the checkpoints of myofibroblast differentiation and profibrotic activity
Abstract
Fibrotic diseases are still a serious concern for public health, due to their high prevalence, complex etiology and lack of successful treatments. Fibrosis consists of excessive accumulation of extracellular matrix components. As a result, the structure and function of tissues are impaired, thus potentially leading to organ failure and death in several chronic diseases. Myofibroblasts represent the principal cellular mediators of fibrosis, due...
Paper Details
Title
Fibrosis: Sirtuins at the checkpoints of myofibroblast differentiation and profibrotic activity
Published Date
Jun 10, 2021
Volume
29
Issue
4
Pages
650 - 666
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