Soluble biomarkers associated with chronic lung disease in older children and adolescents with perinatal HIV infection

Objective: HIV-associated chronic lung disease (HCLD) is a common comorbidity in children and adolescents in sub-Saharan Africa (SSA). The pathogenesis of HCLD is unclear and may be driven by underlying dysregulated systemic immune activation and inflammation. We investigated the association between 26 plasma soluble biomarkers and HCLD. Design: Case--control analysis of baseline biomarker data from 336 children and adolescents (6–19 years old)...