Cyclotriphosphazene-Based "Butterfly" Fluorescence Probe for Lysosome Targeting.

Published on May 24, 2021in Bioconjugate Chemistry4.031
· DOI :10.1021/ACS.BIOCONJCHEM.1C00160
Pan Liu (SUES: Shanghai University of Engineering Sciences), Le Wang4
Estimated H-index: 4
(SUES: Shanghai University of Engineering Sciences)
+ 2 AuthorsXiangyang Shi88
Estimated H-index: 88
(Donghua University)
A cyclotriphosphazene-based "butterfly" fluorescence probe HCCP-MNI bearing two naphthalimide and morpholine units were developed for lysosome targeting. The synthesized HCCP-MNI exhibited stable fluorescence signals and was cytocompatible in the given concentration range. Co-localization experimental results showed that cells treated with the HCCP-MNI and a commercial dye (Lyso-Tracker Red DND-99) had overlapped fluorescence signals, demonstrating its targeting specificity to lysosomes. The developed HCCP-MNI may be used for cell tracking applications associated with the functionalities of lysosomes.
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