A cyclotriphosphazene-based "butterfly" fluorescence probe HCCP-MNI bearing two naphthalimide and morpholine units were developed for lysosome targeting. The synthesized HCCP-MNI exhibited stable fluorescence signals and was cytocompatible in the given concentration range. Co-localization experimental results showed that cells treated with the HCCP-MNI and a commercial dye (Lyso-Tracker Red DND-99) had overlapped fluorescence signals, demonstrating its targeting specificity to lysosomes. The developed HCCP-MNI may be used for cell tracking applications associated with the functionalities of lysosomes.
#1Pan Liu(SUES: Shanghai University of Engineering Sciences)H-Index: 2
#2Le Wang(SUES: Shanghai University of Engineering Sciences)H-Index: 4
Last. Li-June Ming(USF: University of South Florida)H-Index: 1
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ABSTRACT Hexachlorocyclotriphosphazene (HCCP) contains six easily modifiable sites which can be substituted with multi-functional groups to afford various derivatives for broad applications in diverse fields, such as materials science, chemical and biological sensing and imaging, and catalysis. Particularly, when organic dyes such as borondipyrromethene, triarylamine, subphthalocyanines, naphthalimide, fluorene, tetraarylpyrazole, and coumarin are used as substituents that connect to the cyclotr...
#1Jipeng Chen(SUES: Shanghai University of Engineering Sciences)H-Index: 3
#2Le Wang(SUES: Shanghai University of Engineering Sciences)H-Index: 4
Last. Pan Liu(SUES: Shanghai University of Engineering Sciences)H-Index: 2
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Selected 4-oxybenzaldehyde and 2,2-dioxybiphenyl cyclotriphosphazene derivatives were synthesized via substitution reactions through tailored control. The reactions of cyclotriphosphazene with 4-ox...
#1Lingling Li(ECNU: East China Normal University)H-Index: 5
#2Yang Li(CAS: Chinese Academy of Sciences)H-Index: 55
Last. Zhiai Xu(ECNU: East China Normal University)H-Index: 17
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Abstract Intracellular pH is a key physiological factor for controlling the activities and functions of cells and lysosome is a vital subcellular organelle. Thus, developing a novel lysosome-targeting fluorescence probe for selective and sensitive detection of lysosomal pH in living cells is very important. In this work, we synthesized a series of fluorescence probes based on imidazole-fused benzothiadiazole. The optical properties of these probes were easily adjusted by modifying the substituen...
#1Haijun Wang(Huada: Beijing University of Chemical Technology)H-Index: 3
#2Jinle Lan(Huada: Beijing University of Chemical Technology)H-Index: 29
Last. Xiaoping Yang(Huada: Beijing University of Chemical Technology)H-Index: 57
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Abstract Microstructure design combined with high-level heteroatoms doping has been considered the leading approach for preparing the high-performance carbon anodes for sodium-ion batteries (SIBs). Herein, a hollow porous carbon sphere (NP-HPCS) that exhibits a high N, P co-doping level (6.05 at% for N, 5.19 at% for P) and a large microporous specific area (339 m2 g-1) is reported. The microporous and N, P co-doping synergistic construction of the NP-HPCS was achieved by a high-efficiency chemic...
Last. Andrij Pich(UM: Maastricht University)H-Index: 43
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An approach for deposition of a multifunctional coating on the surface of cotton fabric using supercritical carbon dioxide (sc CO2) is explored. Polyphosphazene-based microspheres to be used for deposition are synthesized, and their thermal behavior is studied using thermogravimetric analysis. The morphologies of hydrophobic polymer and polyphosphazene microspheres deposited on cotton fibers from acetonitrile and from sc CO2 are compared using scanning electron microscopy. The results suggest th...
#1Liu Jinghong(GDUT: Guangdong University of Technology)H-Index: 2
#2He Zhuojian(GDUT: Guangdong University of Technology)H-Index: 2
Last. Caihong Lei(GDUT: Guangdong University of Technology)H-Index: 10
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Abstract Developing bioresourced epoxy resin with excellent flame retardancy is challenging for satisfying environmental and fire hazard requirements. Herein, a novel monomer with six functional epoxy groups was successfully synthesized by combining eugenol with hexachlorocyclotriphosphazene. Using aliphatic diamine as a curing agent, a novel epoxy of EHPE-D230 was prepared, and its properties were systematically evaluated. Compared with commercial epoxy resin (E51-D230), EHEP-D230 possessed a h...
#1Pankaj E. Hande(IITB: Indian Institute of Technology Bombay)H-Index: 7
#1Pankaj E. Hande(IITB: Indian Institute of Technology Bombay)
Last. Santosh J. Gharpure(IITB: Indian Institute of Technology Bombay)H-Index: 23
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Intracellular pH plays a significant role in many pathological and physiological processes. A series of quinoline-pyrene probes were synthesized in one-step fashion through an oxonium-ion-triggered alkyne carboamination sequence involving C-C, C-O and C-N bond formation for intracellular pH sensing. The quinoline-pyrenes showed significant red shifts at low pH. Fluorescence lifetime decay measurements of the probes showed decreases in lifetime at pH 4. The probes showed excellent selectivity in ...
Last. Yaron Carmi(TAU: Tel Aviv University)H-Index: 5
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The recent success of checkpoint blockade therapies has established immunotherapy as one of the most promising treatments for melanoma. Nonetheless, a complete curative response following immunotherapy is observed only in a fraction of patients. To identify what factors limit the efficacy of immunotherapies, we established mouse models that cease to respond to immunotherapies once their tumors exceed a certain stage. Analysis of the immune systems of the organisms revealed that the numbers of tu...
Last. Bartosz A. Grzybowski(UNIST: Ulsan National Institute of Science and Technology)H-Index: 79
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Lysosomes have become an important target for anticancer therapeutics because lysosomal cell death bypasses the classical caspase-dependent apoptosis pathway, enabling the targeting of apoptosis- and drug-resistant cancers. However, only a few small molecules—mostly repurposed drugs—have been tested so far, and these typically exhibit low cancer selectivity, making them suitable only for combination therapies. Here, we show that mixed-charge nanoparticles covered with certain ratios of positivel...