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Review paper

Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery

Volume: 16, Issue: 11, Pages: 1261 - 1286
Published: Jun 2, 2021
Abstract
Introduction There continues to be an exponential rise in the number of small molecule drugs that contain either a fluorine atom or a fluorinated fragment. While the unique properties of fluorine enable the precise modulation of a molecule's physicochemical properties, strategic bioisosteric replacement of fragments with fluorinated moieties represents an area of significant growth.Areas covered This review discusses the strategic employment of...
Paper Details
Title
Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery
Published Date
Jun 2, 2021
Volume
16
Issue
11
Pages
1261 - 1286
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