Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
Abstract
Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high levels of DNGR-1 (a.k.a. CLEC9A), a receptor that binds to F-actin exposed by dead cell debris and promotes cross-presentation of associated antigens. Here, we show that secreted gelsolin (sGSN), an extracellular protein, decreases DNGR-1 binding to F-actin and...
Paper Details
Title
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
Published Date
Jul 1, 2021
Journal
Volume
184
Issue
15
Pages
4016 - 4031.e22
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