CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
Abstract
Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only known high-affinity ligand that binds to CCR6 and drives CCR6+ cells' migration in tissues. CCL20 is mainly produced by epithelial cells, and its expression is increased by several folds under inflammatory conditions. Genome-wide association studies (GWAS) in...
Paper Details
Title
CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
Published Date
Jul 1, 2021
Journal
Volume
20
Issue
7
Pages
102846 - 102846
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