Autoimmunity Reviews
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#1Laura Gragnani (UniFI: University of Florence)H-Index: 21
#2Serena Lorini (UniFI: University of Florence)H-Index: 4
Last. Anna Linda Zignego (UniFI: University of Florence)H-Index: 64
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Abstract null null Cryoglobulinemic vasculitis (CV) is the most frequent extrahepatic manifestation during HCV-chronic infection. An effective Direct Acting Antiviral-treatment leads to CV clinical response in the majority of CV-patients although symptoms may persist/recur despite a sustained virological response. At present, no standardized clinical predictive factors for disease maintenance/recurrence were proposed, as emerged from a complete literature review we performed and reported. null H...
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#1Shingo Katayama (Tokyo Medical and Dental University)
#2Tetsuo Kubota (Tokyo Medical and Dental University)H-Index: 24
Last. Hiroki Shiwaku (Tokyo Medical and Dental University)H-Index: 11
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#1Staley A. Brod (MCW: Medical College of Wisconsin)H-Index: 25
Abstract null null Multiple sclerosis (MS) is an inflammatory and degenerative disease of the CNS. An unmet need in MS is repair i.e.,promoting endogenous regeneration and remyelination after demyelinating inflammatory injury. Remyelination is critical in neuronal preservation and the prevention of clinical progression. There is a good deal of evidence for histological repair and remyelination in MS patients. Repair is driven by several prominent endogenous pro-myelinating proteinsincluding neur...
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#1Caiyun Liu (JLU: Jilin University)H-Index: 1
#2Mingchao Shi (JLU: Jilin University)H-Index: 2
Last. Jie Zhu (Karolinska University Hospital)H-Index: 1
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Abstract null null Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) associated with autoantibody (ab) to aquaporin-4 (AQP4). There is obvious variation between regions and countries in the epidemiology, clinical features and management in NMOSD. Based on published population-based observation and cohort studies, the different clinical pattern of NMOSD has been seen in several geographical regions and some of these patient...
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Last. Stéphane Zuily (University of Lorraine)H-Index: 20
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Abstract null null Background null According to criteria for the classification of Systemic Lupus Erythematosus (SLE), autoimmune hemolytic anemia is one of the disease-defining hematologic disorders together with thrombocytopenia. Since the recognition of Antiphospholipid Syndrome (APS), hemolytic anemia was frequently reported but several studies yielded contradictory results on the association between antiphospholipid antibodies (aPL) and hemolytic anemia. Therefore, we evaluated the associat...
1 CitationsSource
Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis...
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#1Barbara Willekens (University of Antwerp)H-Index: 13
#2Inez Wens (University of Antwerp)H-Index: 6
Last. Nathalie Cools (University of Antwerp)H-Index: 25
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In the past years, translational approaches have led to early-stage clinical trials assessing safety and efficacy of tolerance-inducing cell-based treatments in patients. This review aims to determine if tolerance-inducing cell-based therapies, including dendritic cells, regulatory T cells and mesenchymal stem cells, are safe in adult patients who underwent organ transplantation or in those with autoimmune diseases, including multiple sclerosis, diabetes mellitus type 1, Crohn's disease and rheu...
1 CitationsSource
#1Antonio La Cava (UCLA: University of California, Los Angeles)H-Index: 58
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#1Yosta Vegting (UvA: University of Amsterdam)H-Index: 1
#2Liffert Vogt (UvA: University of Amsterdam)H-Index: 22
Last. Marc Hilhorst (UvA: University of Amsterdam)
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Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) are characterized by inflammation of small-to-medium-sized blood vessels and the presence of autoantibodies against cytoplasmic proteases sited in neutrophils and monocytes. Increasing evidence indicates a substantial role of monocytes and macrophages in the pathogenesis of AAV. Activated monocytes and macrophages contribute to necroinflammation in peripheral vasculitic lesions as well as to central and peripheral mechan...
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Last. Kam A. Newman (UCR: University of California, Riverside)H-Index: 9
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