Autoimmunity Reviews
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#1Ferdinando D'Amico (Humanitas University)H-Index: 12
#2Virginia Solitano (Humanitas University)H-Index: 1
Last. Silvio Danese (Humanitas University)H-Index: 82
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Several efforts have been made to improve the available therapeutic armamentarium of patients with immune-mediated inflammatory disorders (IMIDs) leading to the development of biobetters. To date, there is no commonly accepted definition of biobetters. Sixteen physicians with expertise in the field of IMIDs from eleven countries attended a virtual international consensus meeting to provide for the first time a definition of biobetter and to identify unmet needs on this topic. Improvements in cli...
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#1Haoxin Peng (Guangzhou Medical University)H-Index: 1
#2Xiangrong Wu (Guangzhou Medical University)H-Index: 1
Last. Jinsheng Lin (Guangzhou Medical University)
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#1Dario Roccatello (UNITO: University of Turin)H-Index: 39
#2Savino Sciascia (UNITO: University of Turin)H-Index: 32
Last. Daniela Rossi (UNITO: University of Turin)H-Index: 21
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Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only known high-affinity ligand that binds to CCR6 and drives CCR6+ cells' migration in tissues. CCL20 is mainly produced by epithelial cells, and its expression is increased by several folds under inflammatory conditions. Genome-wide association studies (GWAS) in patients with inflammatory bowel disease (IBD), psorias...
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#1Giuseppe Murdaca (UniGe: University of Genoa)H-Index: 31
#2Monica GrecoH-Index: 10
Last. Sebastiano Gangemi (UNIME: University of Messina)H-Index: 36
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Since the start of the "modern era", characterized by the increase in urbanization, a progressive attention to hygiene and autoimmune conditions has considerably grown. Although these diseases are often multifactorial, it was demonstrated that environment factors such as pollution, diet and lifestyles may play a crucial role together with genetic signature. Our research, based on the newest and most significant literature of this topic, highlights that the progressive depletion of microbes and p...
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Galectin family is a group of glycan-binding proteins. Members in this family are expressed in different tissues, immune or non-immune cells. These molecules are important regulators in innate and adaptive immune response, performing significantly in a broad range of cellular and pathophysiological functions, such as cell proliferation, adhesion, migration, and invasion. Findings have shown that expression of galectins is abnormal in many inflammatory autoimmune diseases, such as systemic lupus ...
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#1Naresh Rambabu (French Institute of Health and Medical Research)H-Index: 2
#2Mano Joseph Mathew ('ENS Paris': École Normale Supérieure)H-Index: 1
Last. Jagadeesh Bayry (French Institute of Health and Medical Research)H-Index: 51
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Abstract Intravenous immunoglobulin (IVIG) is used to treat several autoimmune and inflammatory diseases, but some patients are refractory to IVIG and require alternative treatments. Identifying a biomarker that could segregate IVIG responders from non-responders has been a subject of intense research. Unfortunately, previous transcriptomic studies aimed at addressing IVIG resistance have failed to predict a biomarker that could identify IVIG-non-responders. Therefore, we used a novel data minin...
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#1Shiri Keret (Rambam Health Care Campus)
#2Lisa Kaly (Rappaport Faculty of Medicine)H-Index: 2
Last. Gleb Slobodin (Rappaport Faculty of Medicine)H-Index: 20
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Abstract Purpose To reassess the diagnostic approach to a patient with a monoarticular disease in light of the up-to-date medical literature and to examine the practical utility of traditional and newer imaging tools in the setting of monoarthritis. Results The monoarticular disease can represent a medical emergency on the one hand and be a diagnostic conundrum on the other. The management rules of patients with monoarthritis have been established long ago, but various pitfalls still lead physic...
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#1Frédéric Lefebvre (UdeM: Université de Montréal)H-Index: 2
#2Margherita GianniniH-Index: 10
Last. Océane Landon-Cardinal (UdeM: Université de Montréal)H-Index: 8
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Background Scleromyositis (SM) is an emerging subset of myositis associated with features of systemic sclerosis (SSc) but it is currently not recognized as a distinct histopathological subset by the European NeuroMuscular Center (ENMC). Our aim was to review studies reporting muscle biopsies from SSc patients with myositis and to identify unique histopathological features of SM. Methods A scoping review was conducted and included all studies reporting histopathological findings in SSc patients w...
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#1Xu Liu (PRC: China Medical University (PRC))H-Index: 9
#2Yating Zhao (PRC: China Medical University (PRC))H-Index: 1
Last. Jian Zhang (PRC: China Medical University (PRC))
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