Neuronal exosome proteins: novel biomarkers for predicting neonatal response to therapeutic hypothermia

Central nervous system (CNS) derived exosomes can be purified from peripheral blood and have been used widely in adult neurological disease. Application to neonatal neurological disease deserves investigation in the setting of hypoxic-ischaemic encephalopathy (HIE).Observational cohort.Level III neonatal intensive care unit.Term/near-term neonates undergoing therapeutic hypothermia (TH) for HIE.Blood samples were collected at 0-6, 12, 24, 48 and...