Hypoxia signaling in renal pericytes—is it safe to activate?
Abstract
While excitement has grown for the use of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors for treating renal anemia, multiple preclinical studies have shown the complex and cell-type–dependent roles of HIFs in kidney disease pathogenesis, including renal fibrosis. Pan et al. now clearly show that activating the HIF signaling in the Gli1-lineage myofibroblasts restores erythropoietin production while not adversely affecting matrix...
Paper Details
Title
Hypoxia signaling in renal pericytes—is it safe to activate?
Published Date
Jun 1, 2021
Journal
Volume
99
Issue
6
Pages
1267 - 1269
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