Kidney International
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#1Hanna Debiec (French Institute of Health and Medical Research)H-Index: 18
#2Pierre Ronco (French Institute of Health and Medical Research)H-Index: 80
Membranous nephropathy can be associated with various etiologies and antigens. In this issue of Kidney International, Le Quintrec et al. described contactin-1 cell adhesion molecule as a novel target antigen shared by the peripheral nerve and podocyte in patients with neurological disease and membranous nephropathy.
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#1Michael Turner (Clinical Trial Service Unit)
#2Natalie Staplin (Churchill Hospital)
A new Mendelian randomization study finds evidence that genetically predicted higher levels of urinary uromodulin are associated with lower kidney function and higher blood pressure. Bidirectional and multivariable Mendelian randomization suggests the association with higher blood pressure appears to be partially through decreased kidney function, but blood pressure does not appear to mediate the association of uromodulin with low kidney function. We describe the methods used for the bidirection...
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#1Emmanuelle Plaisier (French Institute of Health and Medical Research)H-Index: 24
#2Adeline NotH-Index: 1
Last. Hanna Debiec (French Institute of Health and Medical Research)H-Index: 18
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#1Tilman B. Drüeke (UVSQ: Versailles Saint-Quentin-en-Yvelines University)H-Index: 21
#2Ziad A. Massy (UVSQ: Versailles Saint-Quentin-en-Yvelines University)H-Index: 75
The most important contributors to the anemia of patients with chronic kidney disease are insufficient erythropoietin production and erythropoietin hyporesponsiveness, decreased red blood cell half-life, iron deficiency, and inflammation. However, in contrast to the role of kidney failure, that of proteinuria and nephrotic syndrome is less clear. Bissinger et al. now provide evidence in mouse models and patients with chronic kidney disease that heavy proteinuria alters erythrocyte metabolism and...
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#1Grace Y Chong (Mayo Clinic)H-Index: 1
#2Maroun Chedid (Mayo Clinic)
Last. Fouad T. Chebib (Mayo Clinic)H-Index: 17
view all 4 authors...
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#1Ryunosuke NodaH-Index: 1
#2Daisuke KamanoH-Index: 1
Last. Yoshitaka IshibashiH-Index: 10
view all 9 authors...
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#1Cihan Heybeli (Dokuz Eylül University)H-Index: 1
#2Andrew Bentall (Mayo Clinic)H-Index: 12
Last. Mireille El Ters (Mayo Clinic)H-Index: 5
view all 25 authors...
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#1Tony Lopez (St George’s University Hospitals NHS Foundation Trust)
#2Debasish Banerjee (St George’s University Hospitals NHS Foundation Trust)H-Index: 20
Fluid overload is a common and important complication encountered in the care of patients with end-stage kidney failure receiving hemodialysis. Fluid overload not only causes unpleasant symptomatology for patients on dialysis, but also leads to increased incidence of hospitalization and mortality. Given the association of fluid overload with adverse outcomes in patients with end-stage kidney failure on hemodialysis, it is paramount that we identify effective and reliable methods to determine flu...
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#1Verónica Miguel (RWTH Aachen University)
#2Santiago Lamas (CSIC: Spanish National Research Council)H-Index: 64
The metabolic impairment of kidney tubular cells is a key mechanism underlying the pathophysiology of renal fibrosis. In particular, a drastic reduction in fatty acid oxidation is essentially responsible for the global energy failure occurring in the tubulointerstitial compartment. Piret et al. propose a novel transcriptional regulatory mechanism involving the decrease in the expression of Kruppel-like factor 15 in proximal tubular cells after kidney injury, which results in a major derangement ...
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#1Ryo Yamada (Kyoto University)H-Index: 64
#2Motoko Yanagita (Kyoto University)H-Index: 37
Among v-raf murine sarcoma viral oncogene homolog B1 inhibitors, vemurafenib causes a higher incidence of nephrotoxicity. Bai et al. reported that vemurafenib-induced nephrotoxicity is not directly caused by viral oncogene homolog B1 inhibition but is partly caused by ferrochelatase inhibition in renal tubular epithelial cells. Because several other protein kinase inhibitors are also known to cause ferrochelatase inhibition, further studies are needed to elucidate the role of ferrochelatase in r...
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