Kidney International
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#1Lucie Hénaut (University of Picardie Jules Verne)H-Index: 6
#2Ziad A. Massy (French Institute of Health and Medical Research)H-Index: 57
Cardiovascular disease is highly prevalent in patients with chronic kidney disease. Hyperphosphatemia is associated with subclinical atheromatosis in chronic kidney disease. Phosphate-induced endothelial dysfunction and vascular calcification are thought to be key inducers of atherosclerosis in this condition. Zhou et al. now demonstrate that phosphate promotes de novo cholesterol synthesis in vascular smooth muscle and macrophages through increased 3-hydroxy-3-methylglutaryl coenzyme A reductas...
#1Edward Foley (Georgia Regents University)H-Index: 2
#2Rafael Lombardi (Georgia Regents University)
Last. Vijay Patel (Georgia Regents University)H-Index: 12
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#1Savannah Herbek (Duke University)H-Index: 1
#2Daniel L. Edmonston (Duke University)H-Index: 7
Last. Tomokazu Souma (Duke University)H-Index: 20
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While excitement has grown for the use of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors for treating renal anemia, multiple preclinical studies have shown the complex and cell-type–dependent roles of HIFs in kidney disease pathogenesis, including renal fibrosis. Pan et al. now clearly show that activating the HIF signaling in the Gli1-lineage myofibroblasts restores erythropoietin production while not adversely affecting matrix production, mitigating the concerns of exacerbated fi...
#1Raad Chowdhury (University of Pittsburgh)
#2Manisha Jhamb (University of Pittsburgh)H-Index: 14
Graham-Brown et al. report the results of a randomized controlled trial in patients on hemodialysis in which a 6-month intradialytic cycling program led to significant reduction in left ventricular mass as compared to the control group. However, there was no significant effect on physical function, physical activity or health-related quality of life.
#1Giovanni CancariniH-Index: 34
#2Vincenzo TerlizziH-Index: 3
Last. Letizia ZeniH-Index: 1
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#1Hong Sang ChoiH-Index: 7
#2Chang Seong KimH-Index: 18
Last. Eun Hui BaeH-Index: 23
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#1Janina Paula T. Sy-Go (Mayo Clinic)
#2Prince Mayurank Singh (Mayo Clinic)H-Index: 5
Last. James R. Gregoire (Mayo Clinic)H-Index: 7
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#1Peter Sohn (UCI: University of California, Irvine)
#2Yoko Narasaki (UCI: University of California, Irvine)H-Index: 1
Last. Connie M. Rhee (UCI: University of California, Irvine)H-Index: 35
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Intradialytic hypotension (IDH) is a major complication of hemodialysis, leading to myocardial stunning, cerebral hypoperfusion, gut ischemia, loss of residual kidney function, high symptom burden, and death. This study by Keane et al. provides new data on the incidence of IDH over well-defined time intervals during the hemodialysis treatment session, clinical parameters associated with the timing of IDH onset, and whether timing of IDH impacts survival in a nationally representative hemodialysi...
#1Mustafa KoyunH-Index: 10
Last. Sema AkmanH-Index: 19
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#1Jacob S. StevensH-Index: 3
Last. Sumit MohanH-Index: 26
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Top fields of study
Renal function
Kidney disease
Diabetes mellitus