Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions
Abstract
Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type, and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived from the same individuals and exposed them to a large panel of treatments. Cellular responses involved different genes and pathways for gene expression...
Paper Details
Title
Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions
Published Date
May 14, 2021
Journal
Volume
10
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