Toward Activatable Collagen Mimics: Combining DEPSI “Switch” Defects and Template‐Guided Self‐Organization to Control Collagen Mimetic Peptides

Collagen mimetic peptides (CMPs), which imitate various structural or functional features of natural collagen, constitute advanced models illuminating the folding aspects of the collagen triple helix (CTH) motif. In this study, the CMPs of repeating Gly-Pro-Pro (GPP) triplets are tethered to an organic scaffold based on a tris(2-aminoethyl) amine (TREN) derivative (TREN(sucOH)3 ). These three templated peptide strands are further expanded via...