Statistical harmonization can improve the development of a multicenter CT‐based radiomic model predictive of nonresponse to induction chemotherapy in laryngeal cancers

Purpose To develop a radiomic model predicting nonresponse to induction chemotherapy in laryngeal cancers, from multicenter pretherapeutic contrast‐enhanced computed tomography (CE‐CT) and evaluate the benefit of feature harmonization in such a context. Methods Patients (n = 104) eligible for laryngeal preservation chemotherapy were included in five centers. Primary tumor was manually delineated on the CE‐CT images. The following radiomic...