Medical Physics
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#1Paulo Roberto Costa (USP: Universidade de São Paulo)H-Index: 11
#2Denise Yanikian Nersissian (USP: Universidade de São Paulo)H-Index: 3
Last. José M. Fernández-Varea (UB: University of Barcelona)H-Index: 25
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Purpose null A Monte Carlo (MC) modelling of single axial and helical CT scan mode has been developed to compute single and accumulated dose distributions. The radiation emission characteristics of a MDCT scanner has been modelled and used to evaluate the dose deposition in infinitely-long head and body PMMA phantoms. The simulated accumulated dose distributions determined the approach to equilibrium function, H(L). From these H(L) curves, dose-related information was calculated for different he...
#1Uwe Titt (The University of Texas MD Anderson Cancer Center)H-Index: 31
#2Ming Yang (The University of Texas MD Anderson Cancer Center)H-Index: 14
Last. Radhe Mohan (The University of Texas MD Anderson Cancer Center)H-Index: 116
view all 12 authors...
Purpose null The main purpose of this work was to generate and validate the dosimetric accuracy of proton beams of dimensions that are appropriate for in vivo small animal and in vitro ultra-high dose rate (FLASH) radiotherapy experiments using a synchrotron-based treatment delivery system. This study was performed to enable future investigations of the relevance of a spread-out Bragg peak (SOBP) under FLASH conditions. null Methods null The spill characteristics of the small field fixed horizon...
#1Wang D (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 1
#2Yueju Yin (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)
Last. Jian Zhu (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 2
view all 10 authors...
PURPOSE To identify dosimetric parameters associated with acute hematological toxicity (HT) and identify the corresponding normal tissue complication probability (NTCP) model in cervical cancer patients receiving helical tomotherapy (Tomo) or fixed-field intensity-modulated radiation therapy (ff-IMRT) in combination with chemotherapy, i.e. concurrent chemoradiotherapy (CCRT) using the Lyman-Kutcher-Burman normal tissue complication probability (LKB-NTCP) model. METHODS Data were collected from 2...
#1Hao Gao (KU: University of Kansas)H-Index: 24
#2Jiulong Liu (CAS: Chinese Academy of Sciences)
Last. Ronald C. Chen (KU: University of Kansas)H-Index: 10
view all 11 authors...
PURPOSE Compared to CONV-RT (with conventional dose rate), FLASH-RT (with ultra-high dose rate) can provide biological dose sparing for organs-at-risk (OAR) via the so-called FLASH effect, in addition to physical dose sparing. However, the FLASH effect only occurs, when both dose and dose rate meet certain minimum thresholds. This work will develop a simultaneous dose and dose rate optimization (SDDRO) method accounting for both FLASH dose and dose rate constraints during treatment planning for ...
#1Stefan Stryker (Duke University)H-Index: 2
#2Anuj J. Kapadia (Duke University)H-Index: 12
Last. Joel A. Greenberg (Duke University)H-Index: 13
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PURPOSE Recent studies have demonstrated the ability to rapidly produce large field of view X-ray diffraction (XRD) images, which provide rich new data relevant to the understanding and analysis of disease. However, work has only just begun on developing algorithms that maximize the performance toward decision-making and diagnostic tasks. In this study, we present the implementation of and comparison between rules-based and machine learning (ML) classifiers on XRD images of medically relevant ph...
#1Jörg Steidel (DKFZ: German Cancer Research Center)
#2Joscha Maier (DKFZ: German Cancer Research Center)H-Index: 10
Last. Marc Kachelrieß (DKFZ: German Cancer Research Center)H-Index: 29
view all 4 authors...
PURPOSE Various studies have demonstrated that additional prefilters and/or reduced tube voltages have the potential to significantly increase the contrast-to-noise ratios at unit dose (CNRDs) and thereby to significantly reduce patient dose in clinical CT. An exhaustive analysis, accounting for a wide range of filter thicknesses and a wide range of tube voltages extending beyond the 70 to 150 kV range of today's CT systems, including their specific choice depending on the patient size, is, howe...
#1Lipei Zhang (CAS: Chinese Academy of Sciences)
#2Zizheng Xiao (Sun Yat-sen University)
Last. Hu Zhanli (CAS: Chinese Academy of Sciences)H-Index: 14
view all 12 authors...
Purpose null Positron emission tomography (PET) has been widely used in various clinical applications. PET is a type of emission computed tomography and operates by positron annihilation radiation. With magnetic resonance imaging (MRI) providing anatomical information, joint PET/MRI reduces the radiation exposure risk of patients. Improved hardware and imaging algorithms have been proposed to further decrease the dose from radioactive tracers or the bed duration, but few methods focus on denoisi...
#1Minghui Zhang (SJTU: Shanghai Jiao Tong University)
#2Hong Pan (Swinburne University of Technology)
Last. Yun Gu (SJTU: Shanghai Jiao Tong University)H-Index: 10
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PURPOSE Medical image segmentation is critical for many medical image analysis applications. 3D Convolutional Neural Networks (CNNs) have been widely adopted in the segmentation of volumetric medical images. The recent development of channel-wise attention and spatial-wise attention achieve the state-of-the-art feature representation performance. However, these attention strategies have not explicitly modeled interdependencies among slices in 3D medical volumes. In this work, we propose a novel ...
#1Jérémy Vion-Bailly (University of Lyon System)H-Index: 2
#2Ivan M. Suarez-Castellanos (University of Lyon System)
Last. W. Apoutou N'Djin (University of Lyon System)H-Index: 7
view all 5 authors...
PURPOSE Focused ultrasound (FUS) is a promising tool to develop new modalities of therapeutic neurostimulation. The ability of FUS to stimulate the nervous system, in a noninvasive and spatiotemporally precise manner, has been demonstrated in animals and human subjects, but the underlying biomechanisms are not fully understood yet. The objective of the present study was to investigate the bioeffects involved in the generation of trains of action potentials (APs) by repetitive-pulse FUS stimuli i...
#1Koki Kasamatsu (Hokkaido University)H-Index: 1
#2Sodai Tanaka (Hokkaido University)H-Index: 6
Last. Taeko Matsuura (Hokkaido University)H-Index: 18
view all 11 authors...
PURPOSE In the scanning beam delivery of protons, different portions of the target are irradiated with different linear energy transfer protons with various time intervals and irradiation times. This research aimed to evaluate the spatially dependent biological effectiveness of protracted irradiation in scanning proton therapy. METHODS One and two parallel opposed fields plans were created in water phantom with the prescribed dose of 2 Gy. Three scenarios (instantaneous, continuous, and layered ...
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