Medical Physics
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#1Shu-Ju Tu (CGU: Chang Gung University)
#2Vuong Thuy Tran (CGU: Chang Gung University)
Last. Jing-Ren Tseng (CGU: Chang Gung University)
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PURPOSE In most radiomic studies related to cancer research, the traditional tumor-centric view has predominated. In this retrospective study, we go beyond the single tumor region and investigate the utility of proposed radiomic zones for risk classification and clinical outcome predictions using radiomic features extracted from 11 C-choline positron emission tomography (PET) imaging and supervised machine learning in prostate tumors. MATERIALS AND METHODS Seventy-seven prostate tumors were sele...
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#1Torbjörn Näsmark (Umeå University)
#2Jonas Andersson (Umeå University)H-Index: 18
PURPOSE The purpose of this work was to assess a proof of concept for a novel method for predicting proton stopping power ratios (SPRs) based on a pair of dual-energy CT generated virtual mono-energetic (VM) images. MATERIALS AND METHODS A rapid kV-switching dual-energy CT scanner was used to acquire Gemstone Spectral Imaging (GSI) and 120 kV conventional single-energy CT (SECT) image data of the CIRS 062M phantom. The proposed method was applied to every possible pairing of VM images between 40...
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#1Vicki T. Taasti (Maastricht University Medical Centre)H-Index: 7
#2Djoya Hattu (Maastricht University Medical Centre)H-Index: 1
Last. Wouter van Elmpt (Maastricht University Medical Centre)H-Index: 47
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PURPOSE Intensity-modulated proton therapy (IMPT) for lung tumors with a large tumor movement is challenging due to loss of robustness in the target coverage. Often an upper cut-off at 5-mm tumor movement is used for proton patient selection. In this study, we propose (1) a robust and easily implementable treatment planning strategy for lung tumors with a movement larger than 5 mm, and (2) a four-dimensional computed tomography (4DCT) robust evaluation strategy for evaluating the dose distributi...
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#1Simon Goodall (UWA: University of Western Australia)H-Index: 1
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
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PURPOSE The use of 3D printing to develop custom phantoms for dosimetric studies in radiotherapy is increasing. The process allows production of phantoms designed to evaluated specific geometries, patients or patient groups with a defining feature. The ability to print bone equivalent phantoms has however proved challenging. The purpose of this work was to 3D print a series of three similar spine phantoms containing no surgical implants, implants made of titanium and implants made of carbon-fibr...
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#1Timothy C. Zhu (UPenn: University of Pennsylvania)H-Index: 48
#2Sotiris Stathakis (University of Texas Health Science Center at San Antonio)
Last. Dimitris Mihailidis (UPenn: University of Pennsylvania)H-Index: 9
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Independent verification of the dose per monitor unit (MU) to deliver the prescribed dose to a patient has been a mainstay of radiation oncology quality assurance. We discuss the role of secondary dose/MU calculation programs as part of a comprehensive Quality Assurance (QA) program. This report provides guidelines on calculation-based dose/MU verification for intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) provided by various modalities. We provide a revi...
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#1Monica Abella (Charles III University of Madrid)H-Index: 12
#2Cristobal Martinez (Charles III University of Madrid)
Last. Manuel DescoH-Index: 59
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PURPOSE The last decades have seen the consolidation of the Cone-Beam CT (CBCT) technology, which is nowadays widely used for different applications such as micro-CT for small animals, mammography, dentistry, or surgical procedures. Some CBCT systems may suffer mechanical strains due to the heavy load of the X-ray tube. This fact, together with tolerances in the manufacturing process, lead to different types of undesirable effects in the reconstructed image unless they are properly accounted for...
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#1Rohit Singh (KU: University of Kansas)
#2Janggun Jo (UM: University of Michigan)H-Index: 10
Last. Xinmai Yang (KU: University of Kansas)H-Index: 20
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PURPOSE The current study was aimed to test the feasibility of combined ultrasound and laser technique, namely, ultrasound-assisted endovascular laser thrombolysis (USELT), for thrombolysis by conducting in vivo tests in a rabbit thrombosis model. METHODS An acute thrombus was created in the right jugular vein of rabbit and then was treated with ultrasound only, laser only, and USELT to dissolve the blood clot. A total of 20 rabbits were used. Out of which, the first three rabbits were used to t...
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#1Sebastian Neppl (LMU: Ludwig Maximilian University of Munich)H-Index: 4
#2Christopher Kurz (LMU: Ludwig Maximilian University of Munich)H-Index: 20
Last. Florian Kamp (LMU: Ludwig Maximilian University of Munich)H-Index: 13
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PURPOSE The implementation of volumetric in-room imaging for online adaptive radiotherapy makes extensive testing of this image data for treatment planning necessary. Especially for proton beams the higher sensitivity to stopping power properties of the tissue results in more stringent requirements. Current approaches mainly focus on recalculation of the plans on the new image data, lacking experimental verification, and ignoring the impact on the plan re-optimization process. The aim of this st...
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#1James E. Younkin (Mayo Clinic)H-Index: 6
#2Danairis Hernandez Morales (Mayo Clinic)H-Index: 3
Last. Mirek Fatyga (Mayo Clinic)H-Index: 5
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PURPOSE The multiple energy extraction (MEE) delivery technique for synchrotron-based proton delivery systems reduces beam delivery time by decelerating the beam multiple times during one accelerator spill, but this might cause additional plan quality degradation due to intra-fractional motion. We seek to determine whether MEE causes significantly different plan quality degradation compared to single energy extraction (SEE) for lung cancer treatments due to the interplay effect. METHODS Ten lung...
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#1Jonathon A. Nye (Emory University)H-Index: 27
#2Marina Piccinelli (Emory University)H-Index: 18
Last. Bon-Kwon Koo (Seoul National University Hospital)H-Index: 65
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This work expands on the implementation of 3D normalized gradient fields to correct for whole-body motion and cardiac creep in [N-13]-ammonia patient studies and evaluates its accuracy using a dynamic phantom simulation model. METHODS A full rigid-body algorithm was developed using 3D normalized gradient fields including a multi-resolution step and sampling off the voxel grid to reduce interpolation artifacts. Optimization was performed using a weighted similarity metric that accounts for opposi...
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