Original paper
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
Abstract
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage. The aggressive alveolar subtype is characterized by t(2;13) or t(1;13) translocations encoding for PAX3- or PAX7-FOXO1 chimeric transcription factors, respectively, and are referred to as fusion positive RMS (FP-RMS). The fusion gene alters the myogenic program and maintains the proliferative state while blocking terminal differentiation. Here, we investigated the...
Paper Details
Title
BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
Published Date
Nov 26, 2021
Journal
Volume
12
Issue
1
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Notes
History