Injectable hydrogels with two different rates of drug release based on pluronic/water system filled with poly(ε-caprolactone) microcapsules

The present paper regards the preparation and characterization of Pluronic F127 + F68/water/poly (e-caprolactone) microcapsules (MCs) composite systems for tissue repair. The first part of the work relates to the production of poly(e-caprolactone) (PCL) MCs via water-in-oil-in-water (W/O/W) double emulsion system combined with solvent evaporation method. The study of different process parameters in the final MCs characteristics and their drug...